Some optimal culture conditions for production of cyclosporin a by Fusarium roseum

A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO(3...

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Detalles Bibliográficos
Autores principales: Ismaiel, Ahmed A., El-Sayed, A., Mahmoud, Asmaa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2010
Materias:
Microbial Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769746/
https://www.ncbi.nlm.nih.gov/pubmed/24031594
http://dx.doi.org/10.1590/S1517-838220100004000033
Descripción
Sumario:A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO(3), 2; KH(2)PO(4), 1; MgSO(4).7H(2)O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.

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