Some optimal culture conditions for production of cyclosporin a by Fusarium roseum

A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO(3...

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Autores principales: Ismaiel, Ahmed A., El-Sayed, A., Mahmoud, Asmaa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Microbiologia 2010
Materias:
Microbial Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769746/
https://www.ncbi.nlm.nih.gov/pubmed/24031594
http://dx.doi.org/10.1590/S1517-838220100004000033
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author Ismaiel, Ahmed A.
El-Sayed, A.
Mahmoud, Asmaa A.
author_facet Ismaiel, Ahmed A.
El-Sayed, A.
Mahmoud, Asmaa A.
author_sort Ismaiel, Ahmed A.
collection PubMed
description A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO(3), 2; KH(2)PO(4), 1; MgSO(4).7H(2)O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days.
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spelling pubmed-37697462013-09-12 Some optimal culture conditions for production of cyclosporin a by Fusarium roseum Ismaiel, Ahmed A. El-Sayed, A. Mahmoud, Asmaa A. Braz J Microbiol Microbial Physiology A suitable chemically defined culture medium was selected and some optimal conditions for the production of the highly immunosuppressive compound, cyclosporin A (Cyc A) are reported. Medium of the following composition was favorable for the production of Cyc A by Fusarium roseum: glucose, 30; NaNO(3), 2; KH(2)PO(4), 1; MgSO(4).7H(2)O, 0.5 and KCL, 0.5 (g/l). Maximum productivity of Cyc A was achieved at pH 6.0 when 50 ml of the fermentation medium/250 ml flask, inoculated with five fungal agar discs (6 mm, diameter) of 7-days old F. roseum culture after incubation at 30 ºC at 120 rpm for 7 days. Sociedade Brasileira de Microbiologia 2010 2010-12-01 /pmc/articles/PMC3769746/ /pubmed/24031594 http://dx.doi.org/10.1590/S1517-838220100004000033 Text en © Sociedade Brasileira de Microbiologia http://creativecommons.org/licenses/by-nc/3.0/ All the content of the journal, except where otherwise noted, is licensed under a Creative Commons License
spellingShingle Microbial Physiology
Ismaiel, Ahmed A.
El-Sayed, A.
Mahmoud, Asmaa A.
Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_full Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_fullStr Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_full_unstemmed Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_short Some optimal culture conditions for production of cyclosporin a by Fusarium roseum
title_sort some optimal culture conditions for production of cyclosporin a by fusarium roseum
topic Microbial Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769746/
https://www.ncbi.nlm.nih.gov/pubmed/24031594
http://dx.doi.org/10.1590/S1517-838220100004000033
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