Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense

Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phe...

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Detalles Bibliográficos
Autores principales: Lee, Yen-Chang, Lin, Syh-Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770027/
https://www.ncbi.nlm.nih.gov/pubmed/24066005
http://dx.doi.org/10.1155/2013/427696
Descripción
Sumario:Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and their clinical implications.

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