Cargando…

Disease Modifying Therapies for Alzheimer's Disease Targeting Aβ Oligomers: Implications for Therapeutic Mechanisms

Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Matsubara, Etsuro, Takamura, Ayumi, Okamoto, Yasuhide, Oono, Hideto, Nakata, Takashi, Wakasaya, Yasuhito, Kawarabayashi, Takeshi, Shoji, Mikio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770037/ https://www.ncbi.nlm.nih.gov/pubmed/24063020 http://dx.doi.org/10.1155/2013/984041

Ejemplares similares

Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouse
por: Takamura, Ayumi, et al.
Publicado: (2011)

Alzheimer’s Disease, Oligomers, and Inflammation
por: Forloni, Gianluigi, et al.
Publicado: (2018)

Spastic Paraplegia with Paget's Disease of Bone due to a VCP Gene Mutation
por: Nakamura, Takumi, et al.
Publicado: (2020)

Amyloid β-protein oligomers and Alzheimer’s disease
por: Hayden, Eric Y, et al.
Publicado: (2013)

β-Amyloid oligomers in aging and Alzheimer’s disease
por: Zahs, Kathleen R., et al.
Publicado: (2013)

Tau oligomers in cerebrospinal fluid in Alzheimer's disease
por: Sengupta, Urmi, et al.
Publicado: (2017)

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease
por: Guerrero-Muñoz, Marcos J., et al.
Publicado: (2015)

Severe Chronic Inflammatory Demyelinating Polyneuropathy Ameliorated following High-dose (3 g/kg) Intravenous Immunoglobulin Therapy
por: Seino, Yusuke, et al.
Publicado: (2018)

Perineuritis Successfully Treated with Early Aggressive Immunotherapy
por: Nakamura, Takumi, et al.
Publicado: (2019)

How Fluorescent Tags Modify Oligomer Size Distributions of the Alzheimer Peptide
por: Wägele, Jana, et al.
Publicado: (2019)

Doxycycline for Alzheimer’s Disease: Fighting β-Amyloid Oligomers and Neuroinflammation
por: Balducci, Claudia, et al.
Publicado: (2019)

Synaptic Disruption by Soluble Oligomers in Patients with Alzheimer’s and Parkinson’s Disease
por: Gutierrez, Berenice A., et al.
Publicado: (2022)

Editorial: Beta-Amyloid oligomer specific treatments for Alzheimer's disease
por: Hillen, Heinz
Publicado: (2023)

Environmental Factors Preceding Aβ40 Monomer to Oligomers and the Detection of Oligomers in Alzheimer's Disease Patient Serum
por: Matsunaga, Yoichi, et al.
Publicado: (2012)

CogEvo, a cognitive function balancer, is a sensitive and easy psychiatric test battery for age‐related cognitive decline
por: Ichii, Sadanobu, et al.
Publicado: (2019)

Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases
por: Tsigelny, Igor F., et al.
Publicado: (2008)

Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer’s Disease and Related Tauopathies
por: Castillo-Carranza, Diana L, et al.
Publicado: (2017)

A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer’s Disease by Peptidome Technology
por: Abe, Koji, et al.
Publicado: (2020)

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease
por: Dinamarca, Margarita C., et al.
Publicado: (2012)

Evaluating Amyloid-β Oligomers in Cerebrospinal Fluid as a Biomarker for Alzheimer’s Disease
por: Hölttä, Mikko, et al.
Publicado: (2013)

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease
por: Ferreira, Sergio T., et al.
Publicado: (2015)

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers
por: Sardar Sinha, Maitrayee, et al.
Publicado: (2018)

Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer’s Disease
por: Mroczko, Barbara, et al.
Publicado: (2018)

The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer’s Disease (AD)
por: Mroczko, Barbara, et al.
Publicado: (2019)

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease
por: Hector, Audrey, et al.
Publicado: (2021)

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease
por: Puangmalai, Nicha, et al.
Publicado: (2022)

Quantitative Measurement of Cerebrospinal Fluid Amyloid-β Species by Mass Spectrometry
por: Seino, Yusuke, et al.
Publicado: (2021)

The Small Molecule GAL-201 Efficiently Detoxifies Soluble Amyloid β Oligomers: New Approach towards Oral Disease-Modifying Treatment of Alzheimer’s Disease
por: Russ, Hermann, et al.
Publicado: (2022)

SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians
por: Miyashita, Akinori, et al.
Publicado: (2013)

The past, present, and future of disease-modifying therapies for Alzheimer’s disease
por: SUZUKI, Kazushi, et al.
Publicado: (2017)

Molecular Pathogenesis and Disease-modifying Therapies of Alzheimer’s Disease and Related Disorders
por: Iwatsubo, Takeshi
Publicado: (2022)

Correction: SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians
por: Miyashita, Akinori, et al.
Publicado: (2013)

Aβ40 Oligomers Identified as a Potential Biomarker for the Diagnosis of Alzheimer's Disease
por: Gao, Carol Man, et al.
Publicado: (2010)

Conformation-Dependent Oligomers in Cerebrospinal Fluid of Presymptomatic Familial Alzheimer's Disease Mutation Carriers
por: Ringman, John M., et al.
Publicado: (2012)

Self-Propagative Replication of Aβ Oligomers Suggests Potential Transmissibility in Alzheimer Disease
por: Kumar, Amit, et al.
Publicado: (2014)

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid
por: Herskovits, Adrianna Z., et al.
Publicado: (2013)

Amyloid-β oligomers unveil a novel primate model of sporadic Alzheimer's disease
por: Jebelli, Joseph D., et al.
Publicado: (2015)

Stabilization of a Membrane-Associated Amyloid-β Oligomer for Its Validation in Alzheimer's Disease
por: Serra-Batiste, Montserrat, et al.
Publicado: (2018)

A Rationally Designed Humanized Antibody Selective for Amyloid Beta Oligomers in Alzheimer’s Disease
por: Gibbs, Ebrima, et al.
Publicado: (2019)

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease
por: Ding, Yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_9lfrcjjeuknad81fal3valnttt