Cargando…
Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mell...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770043/ https://www.ncbi.nlm.nih.gov/pubmed/24065991 http://dx.doi.org/10.1155/2013/590569 |
_version_ | 1782284059598127104 |
---|---|
author | Meguro, Shu Kabeya, Yusuke Tanaka, Karin Kawai, Toshihide Tomita, Masuomi Katsuki, Takeshi Oikawa, Yoichi Atsumi, Yoshihito Shimada, Akira Tanaka, Masami Irie, Junichiro Saisho, Yoshifumi Itoh, Hiroshi |
author_facet | Meguro, Shu Kabeya, Yusuke Tanaka, Karin Kawai, Toshihide Tomita, Masuomi Katsuki, Takeshi Oikawa, Yoichi Atsumi, Yoshihito Shimada, Akira Tanaka, Masami Irie, Junichiro Saisho, Yoshifumi Itoh, Hiroshi |
author_sort | Meguro, Shu |
collection | PubMed |
description | Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined “current obesity” as BMI on hospitalization of 25 or more, “previous obesity” as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and “continuously lean” as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P < 0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy. |
format | Online Article Text |
id | pubmed-3770043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37700432013-09-24 Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy Meguro, Shu Kabeya, Yusuke Tanaka, Karin Kawai, Toshihide Tomita, Masuomi Katsuki, Takeshi Oikawa, Yoichi Atsumi, Yoshihito Shimada, Akira Tanaka, Masami Irie, Junichiro Saisho, Yoshifumi Itoh, Hiroshi Int J Endocrinol Clinical Study Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined “current obesity” as BMI on hospitalization of 25 or more, “previous obesity” as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and “continuously lean” as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P < 0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy. Hindawi Publishing Corporation 2013 2013-08-26 /pmc/articles/PMC3770043/ /pubmed/24065991 http://dx.doi.org/10.1155/2013/590569 Text en Copyright © 2013 Shu Meguro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Meguro, Shu Kabeya, Yusuke Tanaka, Karin Kawai, Toshihide Tomita, Masuomi Katsuki, Takeshi Oikawa, Yoichi Atsumi, Yoshihito Shimada, Akira Tanaka, Masami Irie, Junichiro Saisho, Yoshifumi Itoh, Hiroshi Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy |
title | Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy |
title_full | Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy |
title_fullStr | Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy |
title_full_unstemmed | Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy |
title_short | Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy |
title_sort | past obesity as well as present body weight status is a risk factor for diabetic nephropathy |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770043/ https://www.ncbi.nlm.nih.gov/pubmed/24065991 http://dx.doi.org/10.1155/2013/590569 |
work_keys_str_mv | AT meguroshu pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT kabeyayusuke pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT tanakakarin pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT kawaitoshihide pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT tomitamasuomi pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT katsukitakeshi pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT oikawayoichi pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT atsumiyoshihito pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT shimadaakira pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT tanakamasami pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT iriejunichiro pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT saishoyoshifumi pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy AT itohhiroshi pastobesityaswellaspresentbodyweightstatusisariskfactorfordiabeticnephropathy |