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Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy

Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mell...

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Autores principales: Meguro, Shu, Kabeya, Yusuke, Tanaka, Karin, Kawai, Toshihide, Tomita, Masuomi, Katsuki, Takeshi, Oikawa, Yoichi, Atsumi, Yoshihito, Shimada, Akira, Tanaka, Masami, Irie, Junichiro, Saisho, Yoshifumi, Itoh, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770043/
https://www.ncbi.nlm.nih.gov/pubmed/24065991
http://dx.doi.org/10.1155/2013/590569
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author Meguro, Shu
Kabeya, Yusuke
Tanaka, Karin
Kawai, Toshihide
Tomita, Masuomi
Katsuki, Takeshi
Oikawa, Yoichi
Atsumi, Yoshihito
Shimada, Akira
Tanaka, Masami
Irie, Junichiro
Saisho, Yoshifumi
Itoh, Hiroshi
author_facet Meguro, Shu
Kabeya, Yusuke
Tanaka, Karin
Kawai, Toshihide
Tomita, Masuomi
Katsuki, Takeshi
Oikawa, Yoichi
Atsumi, Yoshihito
Shimada, Akira
Tanaka, Masami
Irie, Junichiro
Saisho, Yoshifumi
Itoh, Hiroshi
author_sort Meguro, Shu
collection PubMed
description Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined “current obesity” as BMI on hospitalization of 25 or more, “previous obesity” as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and “continuously lean” as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P < 0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy.
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spelling pubmed-37700432013-09-24 Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy Meguro, Shu Kabeya, Yusuke Tanaka, Karin Kawai, Toshihide Tomita, Masuomi Katsuki, Takeshi Oikawa, Yoichi Atsumi, Yoshihito Shimada, Akira Tanaka, Masami Irie, Junichiro Saisho, Yoshifumi Itoh, Hiroshi Int J Endocrinol Clinical Study Aims. We analyzed the prevalence of nephropathy according to past body weight status in Japanese subjects with type 2 diabetes because the influence of past obesity on diabetic complications is not certain. Methods. We examined the prevalence of nephropathy in 2927 subjects with type 2 diabetes mellitus according to current BMI and maximum BMI in the past. We defined “current obesity” as BMI on hospitalization of 25 or more, “previous obesity” as BMI on hospitalization of less than 25 and self-reported maximum BMI in the past of 25 or more, and “continuously lean” as maximum BMI of less than 25. Results. The prevalence of nephropathy was significantly higher in subjects with current obesity (40.6%) or previous obesity (35.6%) than in those who were continuously lean (24.3%) (P < 0.017). In logistic regression analysis, previous obesity, as well as current obesity, was a significant risk factor for nephropathy, independent of sex, age, disease duration, hypertension, dyslipidemia, HbA1c, and diabetic retinopathy. Conclusions. Obesity in the past, as well as the present body weight status, was a risk factor for diabetic nephropathy. Hindawi Publishing Corporation 2013 2013-08-26 /pmc/articles/PMC3770043/ /pubmed/24065991 http://dx.doi.org/10.1155/2013/590569 Text en Copyright © 2013 Shu Meguro et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Meguro, Shu
Kabeya, Yusuke
Tanaka, Karin
Kawai, Toshihide
Tomita, Masuomi
Katsuki, Takeshi
Oikawa, Yoichi
Atsumi, Yoshihito
Shimada, Akira
Tanaka, Masami
Irie, Junichiro
Saisho, Yoshifumi
Itoh, Hiroshi
Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
title Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
title_full Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
title_fullStr Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
title_full_unstemmed Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
title_short Past Obesity as well as Present Body Weight Status Is a Risk Factor for Diabetic Nephropathy
title_sort past obesity as well as present body weight status is a risk factor for diabetic nephropathy
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770043/
https://www.ncbi.nlm.nih.gov/pubmed/24065991
http://dx.doi.org/10.1155/2013/590569
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