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Sir2 is required for Clr4 to initiate centromeric heterochromatin assembly in fission yeast
Heterochromatin assembly in fission yeast depends on the Clr4 histone methyltransferase, which targets H3K9. We show that the histone deacetylase Sir2 is required for Clr4 activity at telomeres, but acts redundantly with Clr3 histone deacetylase to maintain centromeric heterochromatin. However, Sir2...
Autores principales: | Alper, Benjamin J, Job, Godwin, Yadav, Rajesh K, Shanker, Sreenath, Lowe, Brandon R, Partridge, Janet F |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Molecular Biology Organization
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770337/ https://www.ncbi.nlm.nih.gov/pubmed/23771057 http://dx.doi.org/10.1038/emboj.2013.143 |
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