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4-Bromo-2-[5-methyl-2-(morpholin-4-yl)-1,3-thiazol-4-yl]phenol
In the title compound, C(14)H(15)BrN(2)O(2)S, synthesized by the reaction of the corresponding phenacyl thiocyanate with morpholine, the dihedral angle between the 1,3-thiazole ring and the phenolic substituent ring is 23.46 (10)° as a result of the steric influence of the ortho-methyl group on th...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770429/ https://www.ncbi.nlm.nih.gov/pubmed/24046714 http://dx.doi.org/10.1107/S1600536813017510 |
Sumario: | In the title compound, C(14)H(15)BrN(2)O(2)S, synthesized by the reaction of the corresponding phenacyl thiocyanate with morpholine, the dihedral angle between the 1,3-thiazole ring and the phenolic substituent ring is 23.46 (10)° as a result of the steric influence of the ortho-methyl group on the thiazole ring. A strong intramolecular phenolic O—H⋯N hydrogen bond is present in the molecule. In the crystal, a weak C—H⋯O(phenol) hydrogen bond gives rise to chains lying parallel to [20-1]. A short intermolecular Br⋯O(morpholine) interaction is also present [3.1338 (19) Å]. |
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