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Multicompartmental Pharmacokinetic Model of Tenofovir Delivery by a Vaginal Gel
BACKGROUND: Trials of a vaginal Tenofovir gel for pre-exposure prophylaxis (PrEP) for HIV have given conflicting results. Knowledge of concentrations of Tenofovir and its active form Tenofovir diphosphate, at putative sites of anti-HIV functioning, is central to understanding trial outcomes and desi...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770582/ https://www.ncbi.nlm.nih.gov/pubmed/24040241 http://dx.doi.org/10.1371/journal.pone.0074404 |