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Regulation of FOXOs and p53 by SIRT1 Modulators under Oxidative Stress
Excessive reactive oxygen species (ROS) induce apoptosis and are associated with various diseases and with aging. SIRT1 (sirtuin-1), an NAD+-dependent protein deacetylase, decreases ROS levels and participates in cell survival under oxidative stress conditions. SIRT1 modulates the transcription fact...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770600/ https://www.ncbi.nlm.nih.gov/pubmed/24040102 http://dx.doi.org/10.1371/journal.pone.0073875 |