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The Anti-Tumor Effect of HDAC Inhibition in a Human Pancreas Cancer Model Is Significantly Improved by the Simultaneous Inhibition of Cyclooxygenase 2
Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death worldwide, with no satisfactory treatment to date. In this study, we tested whether the combined inhibition of cyclooxygenase-2 (COX-2) and class I histone deacetylase (HDAC) may results in a better control of pancreatic du...
Autores principales: | Peulen, Olivier, Gonzalez, Arnaud, Peixoto, Paul, Turtoi, Andrei, Mottet, Denis, Delvenne, Philippe, Castronovo, Vincent |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770617/ https://www.ncbi.nlm.nih.gov/pubmed/24040391 http://dx.doi.org/10.1371/journal.pone.0075102 |
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