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Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis
Several studies have used neuroimaging methods to identify neural change in brain networks associated to emotion regulation after psychotherapy of depression and anxiety. In the present work we adopted a meta-analytic technique specific to neuroimaging data to evaluate the consistence of empirical f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770681/ https://www.ncbi.nlm.nih.gov/pubmed/24040309 http://dx.doi.org/10.1371/journal.pone.0074657 |
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author | Messina, Irene Sambin, Marco Palmieri, Arianna Viviani, Roberto |
author_facet | Messina, Irene Sambin, Marco Palmieri, Arianna Viviani, Roberto |
author_sort | Messina, Irene |
collection | PubMed |
description | Several studies have used neuroimaging methods to identify neural change in brain networks associated to emotion regulation after psychotherapy of depression and anxiety. In the present work we adopted a meta-analytic technique specific to neuroimaging data to evaluate the consistence of empirical findings and assess models of therapy that have been proposed in the literature. Meta-analyses were conducted with the Activation Likelihood Estimation technique, which evaluates the overlap between foci of activation across studies. The analysis included 16 studies found in Pubmed (200 foci of activation and 193 patients). Separate meta-analyses were conducted on studies of 1) depression, post-traumatic stress disorder and panic disorder investigated with rest state metabolism (6 studies, 70 patients); 2) depression, post-traumatic stress disorder and panic disorder investigated with task-related activation studies (5 studies, 65 patients); 3) the previous studies considered jointly; and 4) phobias investigated with studies on exposure-related activation (5 studies, 57 patients). Studies on anxiety and depression gave partially consistent results for changes in the dorsomedial prefrontal cortex and in the posterior cingulated gyrus/precuneus. Several areas of change in the temporal lobes were also observed. Studies on the therapy of phobia were consistent with a reduction of activity in medial temporal areas. The cluster of change in the prefrontal cortex may refer to increased recruitment of control processes, as hypothesized by influential models of emotion regulation changes due to psychotherapy. However, not all areas associated with controlled emotion regulation were detected in the meta-analysis, while involvement of midline structures suggested changes in self-related information processing. Changes in phobia were consistent with reduced reactivity to phobic stimuli. |
format | Online Article Text |
id | pubmed-3770681 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37706812013-09-13 Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis Messina, Irene Sambin, Marco Palmieri, Arianna Viviani, Roberto PLoS One Research Article Several studies have used neuroimaging methods to identify neural change in brain networks associated to emotion regulation after psychotherapy of depression and anxiety. In the present work we adopted a meta-analytic technique specific to neuroimaging data to evaluate the consistence of empirical findings and assess models of therapy that have been proposed in the literature. Meta-analyses were conducted with the Activation Likelihood Estimation technique, which evaluates the overlap between foci of activation across studies. The analysis included 16 studies found in Pubmed (200 foci of activation and 193 patients). Separate meta-analyses were conducted on studies of 1) depression, post-traumatic stress disorder and panic disorder investigated with rest state metabolism (6 studies, 70 patients); 2) depression, post-traumatic stress disorder and panic disorder investigated with task-related activation studies (5 studies, 65 patients); 3) the previous studies considered jointly; and 4) phobias investigated with studies on exposure-related activation (5 studies, 57 patients). Studies on anxiety and depression gave partially consistent results for changes in the dorsomedial prefrontal cortex and in the posterior cingulated gyrus/precuneus. Several areas of change in the temporal lobes were also observed. Studies on the therapy of phobia were consistent with a reduction of activity in medial temporal areas. The cluster of change in the prefrontal cortex may refer to increased recruitment of control processes, as hypothesized by influential models of emotion regulation changes due to psychotherapy. However, not all areas associated with controlled emotion regulation were detected in the meta-analysis, while involvement of midline structures suggested changes in self-related information processing. Changes in phobia were consistent with reduced reactivity to phobic stimuli. Public Library of Science 2013-09-11 /pmc/articles/PMC3770681/ /pubmed/24040309 http://dx.doi.org/10.1371/journal.pone.0074657 Text en © 2013 Messina et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Messina, Irene Sambin, Marco Palmieri, Arianna Viviani, Roberto Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis |
title | Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis |
title_full | Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis |
title_fullStr | Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis |
title_full_unstemmed | Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis |
title_short | Neural Correlates of Psychotherapy in Anxiety and Depression: A Meta-Analysis |
title_sort | neural correlates of psychotherapy in anxiety and depression: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770681/ https://www.ncbi.nlm.nih.gov/pubmed/24040309 http://dx.doi.org/10.1371/journal.pone.0074657 |
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