Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ

Atypical protein kinase C isoforms are serine threonine kinases involved in various pathological conditions. In recent years, the PKCζ isoform has emerged as an important regulator of multiple cellular processes operating in cancer. In this review, we will focus on the PKCζ isoform as an oxidative-s...

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Autores principales: Rimessi, Alessandro, Patergnani, Simone, Ioannidi, Elli, Pinton, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770915/
https://www.ncbi.nlm.nih.gov/pubmed/24062985
http://dx.doi.org/10.3389/fonc.2013.00232
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author Rimessi, Alessandro
Patergnani, Simone
Ioannidi, Elli
Pinton, Paolo
author_facet Rimessi, Alessandro
Patergnani, Simone
Ioannidi, Elli
Pinton, Paolo
author_sort Rimessi, Alessandro
collection PubMed
description Atypical protein kinase C isoforms are serine threonine kinases involved in various pathological conditions. In recent years, the PKCζ isoform has emerged as an important regulator of multiple cellular processes operating in cancer. In this review, we will focus on the PKCζ isoform as an oxidative-sensing kinase involved in cancer-related inflammation and chemoresistance. We will discuss its nuclear localization and its possible pivotal role in connecting inflammation with drug resistance.
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spelling pubmed-37709152013-09-23 Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ Rimessi, Alessandro Patergnani, Simone Ioannidi, Elli Pinton, Paolo Front Oncol Oncology Atypical protein kinase C isoforms are serine threonine kinases involved in various pathological conditions. In recent years, the PKCζ isoform has emerged as an important regulator of multiple cellular processes operating in cancer. In this review, we will focus on the PKCζ isoform as an oxidative-sensing kinase involved in cancer-related inflammation and chemoresistance. We will discuss its nuclear localization and its possible pivotal role in connecting inflammation with drug resistance. Frontiers Media S.A. 2013-09-12 /pmc/articles/PMC3770915/ /pubmed/24062985 http://dx.doi.org/10.3389/fonc.2013.00232 Text en Copyright © 2013 Rimessi, Patergnani, Ioannidi and Pinton. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Rimessi, Alessandro
Patergnani, Simone
Ioannidi, Elli
Pinton, Paolo
Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
title Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
title_full Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
title_fullStr Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
title_full_unstemmed Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
title_short Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ
title_sort chemoresistance and cancer-related inflammation: two hallmarks of cancer connected by an atypical link, pkcζ
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770915/
https://www.ncbi.nlm.nih.gov/pubmed/24062985
http://dx.doi.org/10.3389/fonc.2013.00232
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