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Structure-Based, Rational Design of T Cell Receptors

Adoptive cell transfer using engineered T cells is emerging as a promising treatment for metastatic melanoma. Such an approach allows one to introduce T cell receptor (TCR) modifications that, while maintaining the specificity for the targeted antigen, can enhance the binding and kinetic parameters...

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Detalles Bibliográficos
Autores principales:	Zoete, V., Irving, M., Ferber, M., Cuendet, M. A., Michielin, O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2013
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770923/ https://www.ncbi.nlm.nih.gov/pubmed/24062738 http://dx.doi.org/10.3389/fimmu.2013.00268

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