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Dyadic Social Interaction as an Alternative Reward to Cocaine
Individuals suffering from substance use disorders often show severely impaired social interaction, preferring drugs of abuse to the contact with others. Their impaired social interaction is doubly harmful for them as (1) therapy itself is based and dependent on social interaction and as (2) social...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770939/ https://www.ncbi.nlm.nih.gov/pubmed/24062696 http://dx.doi.org/10.3389/fpsyt.2013.00100 |
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author | Zernig, Gerald Kummer, Kai K. Prast, Janine M. |
author_facet | Zernig, Gerald Kummer, Kai K. Prast, Janine M. |
author_sort | Zernig, Gerald |
collection | PubMed |
description | Individuals suffering from substance use disorders often show severely impaired social interaction, preferring drugs of abuse to the contact with others. Their impaired social interaction is doubly harmful for them as (1) therapy itself is based and dependent on social interaction and as (2) social interaction is not available to them as an “alternative”, i.e., non-drug reward, decreasing their motivation to stop drug use. We therefore developed an animal experimental model to investigate the neurobiology of dyadic social interaction- vs. cocaine reward. We took care to avoid: (a) engaging sexual attraction-related aspects of such a social interaction and (b) hierarchical difference as confounding stimuli. The cocaine- or social interaction stimulus was offered – in a mutually exclusive setting – within the confines of a conditioned place preference (CPP) apparatus. In our paradigm, only four 15-min episodes of social interaction proved sufficient to (i) switch the rats’ preference from cocaine-associated contextual stimuli to social interaction CPP and (ii) inhibit the subsequent reacquisition/reexpression of cocaine CPP. This behavioral effect was paralleled by a reversal of brain activation (i.e., EGR1 expression) in the nucleus accumbens, the central and basolateral amygdala, and the ventral tegmental area. Of relevance for the psychotherapy of addictive disorders, the most rewarding sensory component of the composite stimulus “social interaction” was touch. To test our hypothesis that motivation is encoded in neuron ensembles dedicated to specific reward scenarios, we are currently (1) mapping the neural circuits involved in cocaine- vs. social-interaction reward and (2) adapting our paradigm for C57BL/6 mice to make use of the plethora of transgenic models available in this species. |
format | Online Article Text |
id | pubmed-3770939 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-37709392013-09-23 Dyadic Social Interaction as an Alternative Reward to Cocaine Zernig, Gerald Kummer, Kai K. Prast, Janine M. Front Psychiatry Psychiatry Individuals suffering from substance use disorders often show severely impaired social interaction, preferring drugs of abuse to the contact with others. Their impaired social interaction is doubly harmful for them as (1) therapy itself is based and dependent on social interaction and as (2) social interaction is not available to them as an “alternative”, i.e., non-drug reward, decreasing their motivation to stop drug use. We therefore developed an animal experimental model to investigate the neurobiology of dyadic social interaction- vs. cocaine reward. We took care to avoid: (a) engaging sexual attraction-related aspects of such a social interaction and (b) hierarchical difference as confounding stimuli. The cocaine- or social interaction stimulus was offered – in a mutually exclusive setting – within the confines of a conditioned place preference (CPP) apparatus. In our paradigm, only four 15-min episodes of social interaction proved sufficient to (i) switch the rats’ preference from cocaine-associated contextual stimuli to social interaction CPP and (ii) inhibit the subsequent reacquisition/reexpression of cocaine CPP. This behavioral effect was paralleled by a reversal of brain activation (i.e., EGR1 expression) in the nucleus accumbens, the central and basolateral amygdala, and the ventral tegmental area. Of relevance for the psychotherapy of addictive disorders, the most rewarding sensory component of the composite stimulus “social interaction” was touch. To test our hypothesis that motivation is encoded in neuron ensembles dedicated to specific reward scenarios, we are currently (1) mapping the neural circuits involved in cocaine- vs. social-interaction reward and (2) adapting our paradigm for C57BL/6 mice to make use of the plethora of transgenic models available in this species. Frontiers Media S.A. 2013-09-12 /pmc/articles/PMC3770939/ /pubmed/24062696 http://dx.doi.org/10.3389/fpsyt.2013.00100 Text en Copyright © 2013 Zernig, Kummer and Prast. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Zernig, Gerald Kummer, Kai K. Prast, Janine M. Dyadic Social Interaction as an Alternative Reward to Cocaine |
title | Dyadic Social Interaction as an Alternative Reward to Cocaine |
title_full | Dyadic Social Interaction as an Alternative Reward to Cocaine |
title_fullStr | Dyadic Social Interaction as an Alternative Reward to Cocaine |
title_full_unstemmed | Dyadic Social Interaction as an Alternative Reward to Cocaine |
title_short | Dyadic Social Interaction as an Alternative Reward to Cocaine |
title_sort | dyadic social interaction as an alternative reward to cocaine |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770939/ https://www.ncbi.nlm.nih.gov/pubmed/24062696 http://dx.doi.org/10.3389/fpsyt.2013.00100 |
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