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A new form of rapid binocular plasticity in adult with amblyopia

Amblyopia is a neurological disorder of binocular vision affecting up to 3% of the population resulting from a disrupted period of early visual development. Recently, it has been shown that vision can be partially restored by intensive monocular or dichoptic training (4–6 weeks). This can occur even...

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Detalles Bibliográficos
Autores principales: Zhou, Jiawei, Thompson, Benjamin, Hess, Robert F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770967/
https://www.ncbi.nlm.nih.gov/pubmed/24026421
http://dx.doi.org/10.1038/srep02638
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author Zhou, Jiawei
Thompson, Benjamin
Hess, Robert F.
author_facet Zhou, Jiawei
Thompson, Benjamin
Hess, Robert F.
author_sort Zhou, Jiawei
collection PubMed
description Amblyopia is a neurological disorder of binocular vision affecting up to 3% of the population resulting from a disrupted period of early visual development. Recently, it has been shown that vision can be partially restored by intensive monocular or dichoptic training (4–6 weeks). This can occur even in adults owing to a residual degree of brain plasticity initiated by repetitive and successive sensory stimulation. Here we show that the binocular imbalance that characterizes amblyopia can be reduced by occluding the amblyopic eye with a translucent patch for as little as 2.5 hours, suggesting a degree of rapid binocular plasticity in adults resulting from a lack of sensory stimulation. The integrated binocular benefit is larger in our amblyopic group than in our normal control group. We propose that this rapid improvement in function, as a result of reduced sensory stimulation, represents a new form of plasticity operating at a binocular site.
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spelling pubmed-37709672013-09-12 A new form of rapid binocular plasticity in adult with amblyopia Zhou, Jiawei Thompson, Benjamin Hess, Robert F. Sci Rep Article Amblyopia is a neurological disorder of binocular vision affecting up to 3% of the population resulting from a disrupted period of early visual development. Recently, it has been shown that vision can be partially restored by intensive monocular or dichoptic training (4–6 weeks). This can occur even in adults owing to a residual degree of brain plasticity initiated by repetitive and successive sensory stimulation. Here we show that the binocular imbalance that characterizes amblyopia can be reduced by occluding the amblyopic eye with a translucent patch for as little as 2.5 hours, suggesting a degree of rapid binocular plasticity in adults resulting from a lack of sensory stimulation. The integrated binocular benefit is larger in our amblyopic group than in our normal control group. We propose that this rapid improvement in function, as a result of reduced sensory stimulation, represents a new form of plasticity operating at a binocular site. Nature Publishing Group 2013-09-12 /pmc/articles/PMC3770967/ /pubmed/24026421 http://dx.doi.org/10.1038/srep02638 Text en Copyright © 2013, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Zhou, Jiawei
Thompson, Benjamin
Hess, Robert F.
A new form of rapid binocular plasticity in adult with amblyopia
title A new form of rapid binocular plasticity in adult with amblyopia
title_full A new form of rapid binocular plasticity in adult with amblyopia
title_fullStr A new form of rapid binocular plasticity in adult with amblyopia
title_full_unstemmed A new form of rapid binocular plasticity in adult with amblyopia
title_short A new form of rapid binocular plasticity in adult with amblyopia
title_sort new form of rapid binocular plasticity in adult with amblyopia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770967/
https://www.ncbi.nlm.nih.gov/pubmed/24026421
http://dx.doi.org/10.1038/srep02638
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