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Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine

Neonatal stromal cells from umbilical cord blood (CB) are promising alternatives to bone marrow- (BM-) derived multipotent stromal cells (MSCs). In comparison to BM-MSC, the less mature CB-derived stromal cells have been described as a cell population with higher differentiation and proliferation po...

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Detalles Bibliográficos
Autores principales: Kluth, Simone Maria, Radke, Teja Falk, Kogler, Gesine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771124/
https://www.ncbi.nlm.nih.gov/pubmed/24066257
http://dx.doi.org/10.1155/2012/365182
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author Kluth, Simone Maria
Radke, Teja Falk
Kogler, Gesine
author_facet Kluth, Simone Maria
Radke, Teja Falk
Kogler, Gesine
author_sort Kluth, Simone Maria
collection PubMed
description Neonatal stromal cells from umbilical cord blood (CB) are promising alternatives to bone marrow- (BM-) derived multipotent stromal cells (MSCs). In comparison to BM-MSC, the less mature CB-derived stromal cells have been described as a cell population with higher differentiation and proliferation potential that might be of potential interest for clinical application in regenerative medicine. Recently, it has become clear that cord blood contains different stromal cell populations, and as of today, a clear distinction between unrestricted somatic stromal cells (USSCs) and CB-MSC has been established. This classification is based on the expression of DLK-1, HOX, and CD146, as well as functional examination of the adipogenic differentiation potential and the capacity to support haematopoiesis in vitro and in vivo. However, a marker enabling a prospective isolation of the rare cell populations directly out of cord blood is yet to be found. Further analysis may help to reveal even more subpopulations with different properties, which could be useful for the directed application of these cells in preclinical models.
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spelling pubmed-37711242013-09-24 Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine Kluth, Simone Maria Radke, Teja Falk Kogler, Gesine J Blood Transfus Review Article Neonatal stromal cells from umbilical cord blood (CB) are promising alternatives to bone marrow- (BM-) derived multipotent stromal cells (MSCs). In comparison to BM-MSC, the less mature CB-derived stromal cells have been described as a cell population with higher differentiation and proliferation potential that might be of potential interest for clinical application in regenerative medicine. Recently, it has become clear that cord blood contains different stromal cell populations, and as of today, a clear distinction between unrestricted somatic stromal cells (USSCs) and CB-MSC has been established. This classification is based on the expression of DLK-1, HOX, and CD146, as well as functional examination of the adipogenic differentiation potential and the capacity to support haematopoiesis in vitro and in vivo. However, a marker enabling a prospective isolation of the rare cell populations directly out of cord blood is yet to be found. Further analysis may help to reveal even more subpopulations with different properties, which could be useful for the directed application of these cells in preclinical models. Hindawi Publishing Corporation 2012 2012-11-14 /pmc/articles/PMC3771124/ /pubmed/24066257 http://dx.doi.org/10.1155/2012/365182 Text en Copyright © 2012 Simone Maria Kluth et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kluth, Simone Maria
Radke, Teja Falk
Kogler, Gesine
Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
title Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
title_full Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
title_fullStr Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
title_full_unstemmed Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
title_short Potential Application of Cord Blood-Derived Stromal Cells in Cellular Therapy and Regenerative Medicine
title_sort potential application of cord blood-derived stromal cells in cellular therapy and regenerative medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771124/
https://www.ncbi.nlm.nih.gov/pubmed/24066257
http://dx.doi.org/10.1155/2012/365182
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