Cargando…

Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization

Polycystic ovary syndrome (PCOS) has been suggested to be linked with autoimmune processes. Laparoscopic ovarian electrocauterization has the potency to stimulate more autoimmune reactions in PCOS patients. In the present study, we considered anti-nuclear antibodies (ANAs) as the hallmark of autoimm...

Descripción completa

Detalles Bibliográficos
Autores principales: Samsami Dehaghani, Alamtaj, Karimaghaei, Nazanin, Parsanezhad, Mohammad Ebrahim, Malekzadeh, Mahyar, Mehrazmay, Mohammad, Erfani, Nasrollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771222/
https://www.ncbi.nlm.nih.gov/pubmed/24031110
_version_ 1782284173130596352
author Samsami Dehaghani, Alamtaj
Karimaghaei, Nazanin
Parsanezhad, Mohammad Ebrahim
Malekzadeh, Mahyar
Mehrazmay, Mohammad
Erfani, Nasrollah
author_facet Samsami Dehaghani, Alamtaj
Karimaghaei, Nazanin
Parsanezhad, Mohammad Ebrahim
Malekzadeh, Mahyar
Mehrazmay, Mohammad
Erfani, Nasrollah
author_sort Samsami Dehaghani, Alamtaj
collection PubMed
description Polycystic ovary syndrome (PCOS) has been suggested to be linked with autoimmune processes. Laparoscopic ovarian electrocauterization has the potency to stimulate more autoimmune reactions in PCOS patients. In the present study, we considered anti-nuclear antibodies (ANAs) as the hallmark of autoimmune reactions, and investigated the serum level of these antibodies in 35 patients with PCOS (21-38 years old) pre and one-month after electrocauterization, and in 35 fertile healthy women (25-35 years old) as the control group. Serum levels of ANAs, as well as ANA subtyping, were investigated using the Enzyme-Linked Immunosorbent Assay (ELISA). While 3 out of the 35 patients (8.6%) were positive for ANAs before electrocauterization, none of the controls was positive. The number of ANA-positive cases increased following electrocauterization (3 out of 35 [8.6%] before vs. 10 out of 35 [28.6%] after the procedure). The main ANA subtype in the positive samples was SS-A. The higher ANA level among the PCOS patients suggests association of the disease with autoimmune reactions. Laparoscopic ovarian electrocauterization seems to increase the number of positive-ANA patients.
format Online
Article
Text
id pubmed-3771222
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Shiraz University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-37712222013-09-12 Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization Samsami Dehaghani, Alamtaj Karimaghaei, Nazanin Parsanezhad, Mohammad Ebrahim Malekzadeh, Mahyar Mehrazmay, Mohammad Erfani, Nasrollah Iran J Med Sci Brief Report Polycystic ovary syndrome (PCOS) has been suggested to be linked with autoimmune processes. Laparoscopic ovarian electrocauterization has the potency to stimulate more autoimmune reactions in PCOS patients. In the present study, we considered anti-nuclear antibodies (ANAs) as the hallmark of autoimmune reactions, and investigated the serum level of these antibodies in 35 patients with PCOS (21-38 years old) pre and one-month after electrocauterization, and in 35 fertile healthy women (25-35 years old) as the control group. Serum levels of ANAs, as well as ANA subtyping, were investigated using the Enzyme-Linked Immunosorbent Assay (ELISA). While 3 out of the 35 patients (8.6%) were positive for ANAs before electrocauterization, none of the controls was positive. The number of ANA-positive cases increased following electrocauterization (3 out of 35 [8.6%] before vs. 10 out of 35 [28.6%] after the procedure). The main ANA subtype in the positive samples was SS-A. The higher ANA level among the PCOS patients suggests association of the disease with autoimmune reactions. Laparoscopic ovarian electrocauterization seems to increase the number of positive-ANA patients. Shiraz University of Medical Sciences 2013-06 /pmc/articles/PMC3771222/ /pubmed/24031110 Text en © 2013: Iranian Journal of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Samsami Dehaghani, Alamtaj
Karimaghaei, Nazanin
Parsanezhad, Mohammad Ebrahim
Malekzadeh, Mahyar
Mehrazmay, Mohammad
Erfani, Nasrollah
Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization
title Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization
title_full Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization
title_fullStr Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization
title_full_unstemmed Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization
title_short Anti-Nuclear Antibodies in Patients with Polycystic Ovary Syndrome before and after Laparoscopic Electrocauterization
title_sort anti-nuclear antibodies in patients with polycystic ovary syndrome before and after laparoscopic electrocauterization
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771222/
https://www.ncbi.nlm.nih.gov/pubmed/24031110
work_keys_str_mv AT samsamidehaghanialamtaj antinuclearantibodiesinpatientswithpolycysticovarysyndromebeforeandafterlaparoscopicelectrocauterization
AT karimaghaeinazanin antinuclearantibodiesinpatientswithpolycysticovarysyndromebeforeandafterlaparoscopicelectrocauterization
AT parsanezhadmohammadebrahim antinuclearantibodiesinpatientswithpolycysticovarysyndromebeforeandafterlaparoscopicelectrocauterization
AT malekzadehmahyar antinuclearantibodiesinpatientswithpolycysticovarysyndromebeforeandafterlaparoscopicelectrocauterization
AT mehrazmaymohammad antinuclearantibodiesinpatientswithpolycysticovarysyndromebeforeandafterlaparoscopicelectrocauterization
AT erfaninasrollah antinuclearantibodiesinpatientswithpolycysticovarysyndromebeforeandafterlaparoscopicelectrocauterization