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Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shiraz University of Medical Sciences
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771224/ https://www.ncbi.nlm.nih.gov/pubmed/24031112 |
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author | Tagajdid, Mohamed Rida Doblali, Taoufik Elannaz, Hicham Hammi, Salaheddine Belfequih, Bouchra Mrani, Saâd |
author_facet | Tagajdid, Mohamed Rida Doblali, Taoufik Elannaz, Hicham Hammi, Salaheddine Belfequih, Bouchra Mrani, Saâd |
author_sort | Tagajdid, Mohamed Rida |
collection | PubMed |
description | Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveolar lavage. Based on observations on biological data, temporal relationship, and clinical features, it could be inferred that the reactivation of cytomegalovirus with viral replication can predispose a person to TEN-SJS. We discuss here, in the light of the current literature, the probable association between drug-induced SJS-TEN and fulminant reactivation of cytomegalovirus. |
format | Online Article Text |
id | pubmed-3771224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Shiraz University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-37712242013-09-12 Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis Tagajdid, Mohamed Rida Doblali, Taoufik Elannaz, Hicham Hammi, Salaheddine Belfequih, Bouchra Mrani, Saâd Iran J Med Sci Case Report Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe adverse cutaneous reactions to drugs. We describe the case of a 19 year old patient with SJS/TEN overlap syndrome, who developed severe interstitial pneumonia after she had received antiepileptic drugs. A cytomegalovirus infection was diagnosed by Real Time Polymerase Chain Reaction (RT-PCR) detection on Bronchoalveolar lavage. Based on observations on biological data, temporal relationship, and clinical features, it could be inferred that the reactivation of cytomegalovirus with viral replication can predispose a person to TEN-SJS. We discuss here, in the light of the current literature, the probable association between drug-induced SJS-TEN and fulminant reactivation of cytomegalovirus. Shiraz University of Medical Sciences 2013-06 /pmc/articles/PMC3771224/ /pubmed/24031112 Text en © 2013: Iranian Journal of Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Tagajdid, Mohamed Rida Doblali, Taoufik Elannaz, Hicham Hammi, Salaheddine Belfequih, Bouchra Mrani, Saâd Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis |
title | Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis |
title_full | Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis |
title_fullStr | Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis |
title_full_unstemmed | Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis |
title_short | Reactivation of Cytomegalovirus in a Patient with Stevens-Johnson Syndrome-Toxic Epidermal Necrolysis |
title_sort | reactivation of cytomegalovirus in a patient with stevens-johnson syndrome-toxic epidermal necrolysis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771224/ https://www.ncbi.nlm.nih.gov/pubmed/24031112 |
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