Cargando…

The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis

Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No therapy is currently available to completely prevent the initiation or progression of the disease partly due to poor under...

Descripción completa

Detalles Bibliográficos
Autores principales: Maldonado, Maricela, Nam, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771246/
https://www.ncbi.nlm.nih.gov/pubmed/24069595
http://dx.doi.org/10.1155/2013/284873
_version_ 1782284178724749312
author Maldonado, Maricela
Nam, Jin
author_facet Maldonado, Maricela
Nam, Jin
author_sort Maldonado, Maricela
collection PubMed
description Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No therapy is currently available to completely prevent the initiation or progression of the disease partly due to poor understanding of the mechanisms of the disease pathology. Cartilage is the main tissue afflicted by OA, and chondrocytes, the sole cellular component in the tissue, actively participate in the degeneration process. Multiple factors affect the development and progression of OA including inflammation that is sustained during the progression of the disease and alteration in biomechanical conditions due to wear and tear or trauma in cartilage. During the progression of OA, extracellular matrix (ECM) of cartilage is actively remodeled by chondrocytes under inflammatory conditions. This alteration of ECM, in turn, changes the biomechanical environment of chondrocytes, which further drives the progression of the disease in the presence of inflammation. The changes in ECM composition and structure also prevent participation of mesenchymal stem cells in the repair process by inhibiting their chondrogenic differentiation. This review focuses on how inflammation-induced ECM remodeling disturbs cellular activities to prevent self-regeneration of cartilage in the pathology of OA.
format Online
Article
Text
id pubmed-3771246
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37712462013-09-25 The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis Maldonado, Maricela Nam, Jin Biomed Res Int Review Article Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments. No therapy is currently available to completely prevent the initiation or progression of the disease partly due to poor understanding of the mechanisms of the disease pathology. Cartilage is the main tissue afflicted by OA, and chondrocytes, the sole cellular component in the tissue, actively participate in the degeneration process. Multiple factors affect the development and progression of OA including inflammation that is sustained during the progression of the disease and alteration in biomechanical conditions due to wear and tear or trauma in cartilage. During the progression of OA, extracellular matrix (ECM) of cartilage is actively remodeled by chondrocytes under inflammatory conditions. This alteration of ECM, in turn, changes the biomechanical environment of chondrocytes, which further drives the progression of the disease in the presence of inflammation. The changes in ECM composition and structure also prevent participation of mesenchymal stem cells in the repair process by inhibiting their chondrogenic differentiation. This review focuses on how inflammation-induced ECM remodeling disturbs cellular activities to prevent self-regeneration of cartilage in the pathology of OA. Hindawi Publishing Corporation 2013 2013-08-28 /pmc/articles/PMC3771246/ /pubmed/24069595 http://dx.doi.org/10.1155/2013/284873 Text en Copyright © 2013 M. Maldonado and J. Nam. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Maldonado, Maricela
Nam, Jin
The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis
title The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis
title_full The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis
title_fullStr The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis
title_full_unstemmed The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis
title_short The Role of Changes in Extracellular Matrix of Cartilage in the Presence of Inflammation on the Pathology of Osteoarthritis
title_sort role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771246/
https://www.ncbi.nlm.nih.gov/pubmed/24069595
http://dx.doi.org/10.1155/2013/284873
work_keys_str_mv AT maldonadomaricela theroleofchangesinextracellularmatrixofcartilageinthepresenceofinflammationonthepathologyofosteoarthritis
AT namjin theroleofchangesinextracellularmatrixofcartilageinthepresenceofinflammationonthepathologyofosteoarthritis
AT maldonadomaricela roleofchangesinextracellularmatrixofcartilageinthepresenceofinflammationonthepathologyofosteoarthritis
AT namjin roleofchangesinextracellularmatrixofcartilageinthepresenceofinflammationonthepathologyofosteoarthritis