Cargando…

Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia

Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies i...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Hong, Zhang, Jiangbo, Fu, Rong, Liu, Hui, Wang, Huaquan, Ding, Kai, Wang, Yihao, Li, Lijuan, Wang, Honglei, Shao, Zonghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771269/
https://www.ncbi.nlm.nih.gov/pubmed/24069044
http://dx.doi.org/10.1155/2013/730450
_version_ 1782284183933026304
author Yu, Hong
Zhang, Jiangbo
Fu, Rong
Liu, Hui
Wang, Huaquan
Ding, Kai
Wang, Yihao
Li, Lijuan
Wang, Honglei
Shao, Zonghong
author_facet Yu, Hong
Zhang, Jiangbo
Fu, Rong
Liu, Hui
Wang, Huaquan
Ding, Kai
Wang, Yihao
Li, Lijuan
Wang, Honglei
Shao, Zonghong
author_sort Yu, Hong
collection PubMed
description Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on hematopoietic cells membranes by western blot. T follicular helper (Tfh) cells are the true helper cells for Ab responses, which represent one of the most numerous and important subsets of effector T cells. Dysregulation of Tfh cell function or expression of Tfh cell-associated molecules could contribute to the pathogenesis of autoimmune diseases. Currently, there are no studies regarding the role of Tfh cells in IRP patients. The percentages of Tfh cells, Tfh-related molecules ICOS, CD40L, IL-21, and Bcl-6 in BM were investigated in 90 patients with IRP, and 25 healthy controls. We observed that there exist increased quantity and hyperfunction of Tfh cells in IRP, and the results were correlated with patient characteristics. It was indicated that dysregulated Tfh cells might be involved in the pathogenesis of IRP and that inhibition of Tfh cells effector molecules might provide opportunities for new therapeutic approaches to IRP and even other human autoimmune diseases.
format Online
Article
Text
id pubmed-3771269
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-37712692013-09-25 Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia Yu, Hong Zhang, Jiangbo Fu, Rong Liu, Hui Wang, Huaquan Ding, Kai Wang, Yihao Li, Lijuan Wang, Honglei Shao, Zonghong Clin Dev Immunol Clinical Study Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on hematopoietic cells membranes by western blot. T follicular helper (Tfh) cells are the true helper cells for Ab responses, which represent one of the most numerous and important subsets of effector T cells. Dysregulation of Tfh cell function or expression of Tfh cell-associated molecules could contribute to the pathogenesis of autoimmune diseases. Currently, there are no studies regarding the role of Tfh cells in IRP patients. The percentages of Tfh cells, Tfh-related molecules ICOS, CD40L, IL-21, and Bcl-6 in BM were investigated in 90 patients with IRP, and 25 healthy controls. We observed that there exist increased quantity and hyperfunction of Tfh cells in IRP, and the results were correlated with patient characteristics. It was indicated that dysregulated Tfh cells might be involved in the pathogenesis of IRP and that inhibition of Tfh cells effector molecules might provide opportunities for new therapeutic approaches to IRP and even other human autoimmune diseases. Hindawi Publishing Corporation 2013 2013-08-27 /pmc/articles/PMC3771269/ /pubmed/24069044 http://dx.doi.org/10.1155/2013/730450 Text en Copyright © 2013 Hong Yu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Yu, Hong
Zhang, Jiangbo
Fu, Rong
Liu, Hui
Wang, Huaquan
Ding, Kai
Wang, Yihao
Li, Lijuan
Wang, Honglei
Shao, Zonghong
Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
title Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
title_full Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
title_fullStr Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
title_full_unstemmed Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
title_short Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
title_sort increased frequency of bone marrow t follicular helper cells in patients with immune-related pancytopenia
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771269/
https://www.ncbi.nlm.nih.gov/pubmed/24069044
http://dx.doi.org/10.1155/2013/730450
work_keys_str_mv AT yuhong increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT zhangjiangbo increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT furong increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT liuhui increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT wanghuaquan increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT dingkai increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT wangyihao increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT lilijuan increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT wanghonglei increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia
AT shaozonghong increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia