Cargando…
Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia
Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies i...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771269/ https://www.ncbi.nlm.nih.gov/pubmed/24069044 http://dx.doi.org/10.1155/2013/730450 |
_version_ | 1782284183933026304 |
---|---|
author | Yu, Hong Zhang, Jiangbo Fu, Rong Liu, Hui Wang, Huaquan Ding, Kai Wang, Yihao Li, Lijuan Wang, Honglei Shao, Zonghong |
author_facet | Yu, Hong Zhang, Jiangbo Fu, Rong Liu, Hui Wang, Huaquan Ding, Kai Wang, Yihao Li, Lijuan Wang, Honglei Shao, Zonghong |
author_sort | Yu, Hong |
collection | PubMed |
description | Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on hematopoietic cells membranes by western blot. T follicular helper (Tfh) cells are the true helper cells for Ab responses, which represent one of the most numerous and important subsets of effector T cells. Dysregulation of Tfh cell function or expression of Tfh cell-associated molecules could contribute to the pathogenesis of autoimmune diseases. Currently, there are no studies regarding the role of Tfh cells in IRP patients. The percentages of Tfh cells, Tfh-related molecules ICOS, CD40L, IL-21, and Bcl-6 in BM were investigated in 90 patients with IRP, and 25 healthy controls. We observed that there exist increased quantity and hyperfunction of Tfh cells in IRP, and the results were correlated with patient characteristics. It was indicated that dysregulated Tfh cells might be involved in the pathogenesis of IRP and that inhibition of Tfh cells effector molecules might provide opportunities for new therapeutic approaches to IRP and even other human autoimmune diseases. |
format | Online Article Text |
id | pubmed-3771269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37712692013-09-25 Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia Yu, Hong Zhang, Jiangbo Fu, Rong Liu, Hui Wang, Huaquan Ding, Kai Wang, Yihao Li, Lijuan Wang, Honglei Shao, Zonghong Clin Dev Immunol Clinical Study Immune-related pancytopenia (IRP) is one kind of bone marrow failure diseases which is related to autoantibodies. Autoantibodies have been detected on the membrane of various bone marrow (BM) hemopoietic cells by BM mononuclear-cell-Coombs test or flow cytometric analysis. There are autoantibodies in the BM supernatant of IRP patients, which can target several antigens on hematopoietic cells membranes by western blot. T follicular helper (Tfh) cells are the true helper cells for Ab responses, which represent one of the most numerous and important subsets of effector T cells. Dysregulation of Tfh cell function or expression of Tfh cell-associated molecules could contribute to the pathogenesis of autoimmune diseases. Currently, there are no studies regarding the role of Tfh cells in IRP patients. The percentages of Tfh cells, Tfh-related molecules ICOS, CD40L, IL-21, and Bcl-6 in BM were investigated in 90 patients with IRP, and 25 healthy controls. We observed that there exist increased quantity and hyperfunction of Tfh cells in IRP, and the results were correlated with patient characteristics. It was indicated that dysregulated Tfh cells might be involved in the pathogenesis of IRP and that inhibition of Tfh cells effector molecules might provide opportunities for new therapeutic approaches to IRP and even other human autoimmune diseases. Hindawi Publishing Corporation 2013 2013-08-27 /pmc/articles/PMC3771269/ /pubmed/24069044 http://dx.doi.org/10.1155/2013/730450 Text en Copyright © 2013 Hong Yu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Yu, Hong Zhang, Jiangbo Fu, Rong Liu, Hui Wang, Huaquan Ding, Kai Wang, Yihao Li, Lijuan Wang, Honglei Shao, Zonghong Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia |
title | Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia |
title_full | Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia |
title_fullStr | Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia |
title_full_unstemmed | Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia |
title_short | Increased Frequency of Bone Marrow T Follicular Helper Cells in Patients with Immune-Related Pancytopenia |
title_sort | increased frequency of bone marrow t follicular helper cells in patients with immune-related pancytopenia |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771269/ https://www.ncbi.nlm.nih.gov/pubmed/24069044 http://dx.doi.org/10.1155/2013/730450 |
work_keys_str_mv | AT yuhong increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT zhangjiangbo increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT furong increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT liuhui increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT wanghuaquan increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT dingkai increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT wangyihao increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT lilijuan increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT wanghonglei increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia AT shaozonghong increasedfrequencyofbonemarrowtfollicularhelpercellsinpatientswithimmunerelatedpancytopenia |