Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine

Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transderm...

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Detalles Bibliográficos
Autores principales: Hong, Xiaoyun, Wei, Liangming, Wu, Fei, Wu, Zaozhan, Chen, Lizhu, Liu, Zhenguo, Yuan, Weien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771849/
https://www.ncbi.nlm.nih.gov/pubmed/24039404
http://dx.doi.org/10.2147/DDDT.S44401
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author Hong, Xiaoyun
Wei, Liangming
Wu, Fei
Wu, Zaozhan
Chen, Lizhu
Liu, Zhenguo
Yuan, Weien
author_facet Hong, Xiaoyun
Wei, Liangming
Wu, Fei
Wu, Zaozhan
Chen, Lizhu
Liu, Zhenguo
Yuan, Weien
author_sort Hong, Xiaoyun
collection PubMed
description Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation.
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spelling pubmed-37718492013-09-13 Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine Hong, Xiaoyun Wei, Liangming Wu, Fei Wu, Zaozhan Chen, Lizhu Liu, Zhenguo Yuan, Weien Drug Des Devel Ther Review Microneedles were first conceptualized for drug delivery many decades ago, overcoming the shortages and preserving the advantages of hypodermic needle and conventional transdermal drug-delivery systems to some extent. Dissolving and biodegradable microneedle technologies have been used for transdermal sustained deliveries of different drugs and vaccines. This review describes microneedle geometry and the representative dissolving and biodegradable microneedle delivery methods via the skin, followed by the fabricating methods. Finally, this review puts forward some perspectives that require further investigation. Dove Medical Press 2013-09-04 /pmc/articles/PMC3771849/ /pubmed/24039404 http://dx.doi.org/10.2147/DDDT.S44401 Text en © 2013 Hong et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.
spellingShingle Review
Hong, Xiaoyun
Wei, Liangming
Wu, Fei
Wu, Zaozhan
Chen, Lizhu
Liu, Zhenguo
Yuan, Weien
Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
title Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
title_full Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
title_fullStr Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
title_full_unstemmed Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
title_short Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
title_sort dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771849/
https://www.ncbi.nlm.nih.gov/pubmed/24039404
http://dx.doi.org/10.2147/DDDT.S44401
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