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Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells

Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in endothelial cells stimulates endothelial cell adhesiveness...

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Detalles Bibliográficos
Autores principales: Potapova, Irina A., Cohen, Ira S., Doronin, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771880/
https://www.ncbi.nlm.nih.gov/pubmed/24069252
http://dx.doi.org/10.1371/journal.pone.0073929
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author Potapova, Irina A.
Cohen, Ira S.
Doronin, Sergey V.
author_facet Potapova, Irina A.
Cohen, Ira S.
Doronin, Sergey V.
author_sort Potapova, Irina A.
collection PubMed
description Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in endothelial cells stimulates endothelial cell adhesiveness for mesenchymal stem cells. Adhesion of mesenchymal stem cells to apoptotic endothelial cells depends on the activation of endothelial caspases and p38 MAPK. Activation of p38 MAPK in endothelial cells has a primary effect while the activation of caspases potentiates the mesenchymal stem cell adhesion. Overall, our study of the mesenchymal stem cell interaction with endothelial cells indicates that mesenchymal stem cells recognize and specifically adhere to distressed/apoptotic endothelial cells.
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spelling pubmed-37718802013-09-25 Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells Potapova, Irina A. Cohen, Ira S. Doronin, Sergey V. PLoS One Research Article Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in endothelial cells stimulates endothelial cell adhesiveness for mesenchymal stem cells. Adhesion of mesenchymal stem cells to apoptotic endothelial cells depends on the activation of endothelial caspases and p38 MAPK. Activation of p38 MAPK in endothelial cells has a primary effect while the activation of caspases potentiates the mesenchymal stem cell adhesion. Overall, our study of the mesenchymal stem cell interaction with endothelial cells indicates that mesenchymal stem cells recognize and specifically adhere to distressed/apoptotic endothelial cells. Public Library of Science 2013-09-12 /pmc/articles/PMC3771880/ /pubmed/24069252 http://dx.doi.org/10.1371/journal.pone.0073929 Text en © 2013 Potapova et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Potapova, Irina A.
Cohen, Ira S.
Doronin, Sergey V.
Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
title Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
title_full Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
title_fullStr Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
title_full_unstemmed Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
title_short Caspases and p38 MAPK Regulate Endothelial Cell Adhesiveness for Mesenchymal Stem Cells
title_sort caspases and p38 mapk regulate endothelial cell adhesiveness for mesenchymal stem cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771880/
https://www.ncbi.nlm.nih.gov/pubmed/24069252
http://dx.doi.org/10.1371/journal.pone.0073929
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