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Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes

Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of infected hepatocyte and serves as the transcriptional template for viral mRNA synthesis. Elimination of cccDNA is the prerequisite for either a therapeutic cure or immunological resolutio...

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Detalles Bibliográficos
Autores principales:	Liu, Fei, Campagna, Matthew, Qi, Yonghe, Zhao, Xuesen, Guo, Fang, Xu, Chunxiao, Li, Sichen, Li, Wenhui, Block, Timothy M., Chang, Jinhong, Guo, Ju-Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771898/ https://www.ncbi.nlm.nih.gov/pubmed/24068929 http://dx.doi.org/10.1371/journal.ppat.1003613

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