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SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria

Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive forms of Parkinson's disease. Recent work suggests that loss of mitochondrial membrane potential stabilizes PINK1 and that accumulated PINK1 recruits parkin from the cytoplasm to mitochondria for elimination...

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Detalles Bibliográficos
Autores principales:	Murata, Hitoshi, Sakaguchi, Masakiyo, Kataoka, Ken, Huh, Nam-ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771941/ https://www.ncbi.nlm.nih.gov/pubmed/23885119 http://dx.doi.org/10.1091/mbc.E13-01-0016

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