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Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets
BACKGROUND: The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are i...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772001/ https://www.ncbi.nlm.nih.gov/pubmed/24069483 http://dx.doi.org/10.1371/journal.pntd.0002428 |