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Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s

BACKGROUND: Our aim is to explore the trend of association between the survival rates of colorectal cancer (CRC) and the different clinical characteristics in patients registered from 1960s to 2000s. We hypothesized that the survival rate of CRC increases over time and varies according to anatomic s...

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Autores principales: Fang, Yu-Jing, Wu, Xiao-Jun, Zhao, Qian, Li, Li-Ren, Lu, Zhen-Hai, Ding, Pei-Rong, Zhang, Rong-Xin, Kong, Ling-Heng, Wang, Fu-Long, Lin, Jun-Zhong, Chen, Gong, Pan, Zhi-Zhong, Wan, De-Sen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772028/
https://www.ncbi.nlm.nih.gov/pubmed/24069202
http://dx.doi.org/10.1371/journal.pone.0073528
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author Fang, Yu-Jing
Wu, Xiao-Jun
Zhao, Qian
Li, Li-Ren
Lu, Zhen-Hai
Ding, Pei-Rong
Zhang, Rong-Xin
Kong, Ling-Heng
Wang, Fu-Long
Lin, Jun-Zhong
Chen, Gong
Pan, Zhi-Zhong
Wan, De-Sen
author_facet Fang, Yu-Jing
Wu, Xiao-Jun
Zhao, Qian
Li, Li-Ren
Lu, Zhen-Hai
Ding, Pei-Rong
Zhang, Rong-Xin
Kong, Ling-Heng
Wang, Fu-Long
Lin, Jun-Zhong
Chen, Gong
Pan, Zhi-Zhong
Wan, De-Sen
author_sort Fang, Yu-Jing
collection PubMed
description BACKGROUND: Our aim is to explore the trend of association between the survival rates of colorectal cancer (CRC) and the different clinical characteristics in patients registered from 1960s to 2000s. We hypothesized that the survival rate of CRC increases over time and varies according to anatomic subsites. METHODS: Information from a total of 4558 stage T((1-4))N((1-2))M(0) CRC patients registered from 1960s to 2008 were analyzed. The association of CRC overall survival with age, gender, tumor locations, time, histopathology types, pathology grades, no. of examined lymph nodes, the T stage, and the N stage was analyzed. The assessment of the influence of prognostic factors on patient survival was performed using Cox’s proportional hazard regression models. RESULTS: From 1960 to 2008, the studied CRC patients included 2625 (57.6%) and 1933 (42.4%) males and females, respectively. These included 1896 (41.6%) colon cancers, and 2662 (58.4%) rectum cancers. The 5-year survival rate was 49%, 58%, 58%, 70%, and 77% for the time duration of 1960s, 1970s, 1980s, 1990s and 2000s, respectively. An increased 5-year survival rate was observed in the colon cancer and rectum cancer patients. Patients older than 60 years of age were more likely to develop colonic cancer (sigmoid) than rectum cancer (49.2% vs. 39.9%). The Cox regression model showed that only rectum cancer survival was related to time duration. CONCLUSION: The overall survival and 5-year survival rates showed an increase from the 1960s to 2000s. There is a trend of rightward shift of tumor location in CRC patients.
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spelling pubmed-37720282013-09-25 Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s Fang, Yu-Jing Wu, Xiao-Jun Zhao, Qian Li, Li-Ren Lu, Zhen-Hai Ding, Pei-Rong Zhang, Rong-Xin Kong, Ling-Heng Wang, Fu-Long Lin, Jun-Zhong Chen, Gong Pan, Zhi-Zhong Wan, De-Sen PLoS One Research Article BACKGROUND: Our aim is to explore the trend of association between the survival rates of colorectal cancer (CRC) and the different clinical characteristics in patients registered from 1960s to 2000s. We hypothesized that the survival rate of CRC increases over time and varies according to anatomic subsites. METHODS: Information from a total of 4558 stage T((1-4))N((1-2))M(0) CRC patients registered from 1960s to 2008 were analyzed. The association of CRC overall survival with age, gender, tumor locations, time, histopathology types, pathology grades, no. of examined lymph nodes, the T stage, and the N stage was analyzed. The assessment of the influence of prognostic factors on patient survival was performed using Cox’s proportional hazard regression models. RESULTS: From 1960 to 2008, the studied CRC patients included 2625 (57.6%) and 1933 (42.4%) males and females, respectively. These included 1896 (41.6%) colon cancers, and 2662 (58.4%) rectum cancers. The 5-year survival rate was 49%, 58%, 58%, 70%, and 77% for the time duration of 1960s, 1970s, 1980s, 1990s and 2000s, respectively. An increased 5-year survival rate was observed in the colon cancer and rectum cancer patients. Patients older than 60 years of age were more likely to develop colonic cancer (sigmoid) than rectum cancer (49.2% vs. 39.9%). The Cox regression model showed that only rectum cancer survival was related to time duration. CONCLUSION: The overall survival and 5-year survival rates showed an increase from the 1960s to 2000s. There is a trend of rightward shift of tumor location in CRC patients. Public Library of Science 2013-09-12 /pmc/articles/PMC3772028/ /pubmed/24069202 http://dx.doi.org/10.1371/journal.pone.0073528 Text en © 2013 Fang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Fang, Yu-Jing
Wu, Xiao-Jun
Zhao, Qian
Li, Li-Ren
Lu, Zhen-Hai
Ding, Pei-Rong
Zhang, Rong-Xin
Kong, Ling-Heng
Wang, Fu-Long
Lin, Jun-Zhong
Chen, Gong
Pan, Zhi-Zhong
Wan, De-Sen
Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s
title Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s
title_full Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s
title_fullStr Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s
title_full_unstemmed Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s
title_short Hospital-Based Colorectal Cancer Survival Trend of Different Tumor Locations from 1960s to 2000s
title_sort hospital-based colorectal cancer survival trend of different tumor locations from 1960s to 2000s
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772028/
https://www.ncbi.nlm.nih.gov/pubmed/24069202
http://dx.doi.org/10.1371/journal.pone.0073528
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