How are STAT1 and cholesterol metabolism associated in antiviral responses?

Sterol metabolites are known to be associated with immune responses. 25-Hydroxycholesterol (25HC) is a cholesterol metabolite that is produced by macrophages. The production of 25HC was reported to be TLR-dependent, indicating the involvement of 25HC in innate immunity. Now Blanc et al. show that ma...

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Detalles Bibliográficos
Autores principales: Matsumiya, Tomoh, Imaizumi, Tadaatsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772106/
https://www.ncbi.nlm.nih.gov/pubmed/24069554
http://dx.doi.org/10.4161/jkst.24189
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author Matsumiya, Tomoh
Imaizumi, Tadaatsu
author_facet Matsumiya, Tomoh
Imaizumi, Tadaatsu
author_sort Matsumiya, Tomoh
collection PubMed
description Sterol metabolites are known to be associated with immune responses. 25-Hydroxycholesterol (25HC) is a cholesterol metabolite that is produced by macrophages. The production of 25HC was reported to be TLR-dependent, indicating the involvement of 25HC in innate immunity. Now Blanc et al. show that macrophages synthesize 25HC to exert an antiviral effect. STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity.
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spelling pubmed-37721062013-09-25 How are STAT1 and cholesterol metabolism associated in antiviral responses? Matsumiya, Tomoh Imaizumi, Tadaatsu JAKSTAT Commentary Sterol metabolites are known to be associated with immune responses. 25-Hydroxycholesterol (25HC) is a cholesterol metabolite that is produced by macrophages. The production of 25HC was reported to be TLR-dependent, indicating the involvement of 25HC in innate immunity. Now Blanc et al. show that macrophages synthesize 25HC to exert an antiviral effect. STAT1 was shown to be the most essential transcriptional factor involved in the induction of cholesterol 25-hydroxylase (Ch25h), the enzyme required to produce 25HC, indicating the importance of STAT1 in oxysterol-mediated innate immunity. Landes Bioscience 2013-07-01 2013-08-15 /pmc/articles/PMC3772106/ /pubmed/24069554 http://dx.doi.org/10.4161/jkst.24189 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
Matsumiya, Tomoh
Imaizumi, Tadaatsu
How are STAT1 and cholesterol metabolism associated in antiviral responses?
title How are STAT1 and cholesterol metabolism associated in antiviral responses?
title_full How are STAT1 and cholesterol metabolism associated in antiviral responses?
title_fullStr How are STAT1 and cholesterol metabolism associated in antiviral responses?
title_full_unstemmed How are STAT1 and cholesterol metabolism associated in antiviral responses?
title_short How are STAT1 and cholesterol metabolism associated in antiviral responses?
title_sort how are stat1 and cholesterol metabolism associated in antiviral responses?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772106/
https://www.ncbi.nlm.nih.gov/pubmed/24069554
http://dx.doi.org/10.4161/jkst.24189
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