JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells

The identification of a constitutively active JAK2 mutant, namely JAK2-V617F, was a milestone in the understanding of Philadelphia chromosome-negative myeloproliferative neoplasms. The JAK2-V617F mutation confers cytokine hypersensitivity, constitutive activation of the JAK-STAT pathway, and cytokin...

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Detalles Bibliográficos
Autores principales: Wolf, Alexandra, Eulenfeld, René, Gäbler, Karoline, Rolvering, Catherine, Haan, Serge, Behrmann, Iris, Denecke, Bernd, Haan, Claude, Schaper, Fred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772110/
https://www.ncbi.nlm.nih.gov/pubmed/24069558
http://dx.doi.org/10.4161/jkst.24574

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