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JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
The Janus kinase 2 (JAK2) mutant V617F and other JAK mutants are found in patients with myeloproliferative neoplasms and leukemias. Due to their involvement in neoplasia and inflammatory disorders, Janus kinases are promising targets for kinase inhibitor therapy. Several small-molecule compounds are...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772115/ https://www.ncbi.nlm.nih.gov/pubmed/24069563 http://dx.doi.org/10.4161/jkst.25025 |