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JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms

The Janus kinase 2 (JAK2) mutant V617F and other JAK mutants are found in patients with myeloproliferative neoplasms and leukemias. Due to their involvement in neoplasia and inflammatory disorders, Janus kinases are promising targets for kinase inhibitor therapy. Several small-molecule compounds are...

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Detalles Bibliográficos
Autores principales:	Gäbler, Karoline, Behrmann, Iris, Haan, Claude
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Landes Bioscience 2013
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772115/ https://www.ncbi.nlm.nih.gov/pubmed/24069563 http://dx.doi.org/10.4161/jkst.25025

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