The Drosophila JAK-STAT pathway

The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species. Here...

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Detalles Bibliográficos
Autores principales: Zeidler, Martin P, Bausek, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Special Focus Letter from the Guest Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772116/
https://www.ncbi.nlm.nih.gov/pubmed/24069564
http://dx.doi.org/10.4161/jkst.25353
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author Zeidler, Martin P
Bausek, Nina
author_facet Zeidler, Martin P
Bausek, Nina
author_sort Zeidler, Martin P
collection PubMed
description The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species. Here we review the background to how the pathway was first identified and the first characterization of JAK-STAT pathway phenotypes in the Drosophila system, highlighting the molecular, functional, and disease-related conservation of the pathway.
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spelling pubmed-37721162013-09-25 The Drosophila JAK-STAT pathway Zeidler, Martin P Bausek, Nina JAKSTAT Special Focus Letter from the Guest Editor The conservation of signaling cascades between humans and Drosophila, over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species. Here we review the background to how the pathway was first identified and the first characterization of JAK-STAT pathway phenotypes in the Drosophila system, highlighting the molecular, functional, and disease-related conservation of the pathway. Landes Bioscience 2013-07-01 2013-08-01 /pmc/articles/PMC3772116/ /pubmed/24069564 http://dx.doi.org/10.4161/jkst.25353 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Special Focus Letter from the Guest Editor
Zeidler, Martin P
Bausek, Nina
The Drosophila JAK-STAT pathway
title The Drosophila JAK-STAT pathway
title_full The Drosophila JAK-STAT pathway
title_fullStr The Drosophila JAK-STAT pathway
title_full_unstemmed The Drosophila JAK-STAT pathway
title_short The Drosophila JAK-STAT pathway
title_sort drosophila jak-stat pathway
topic Special Focus Letter from the Guest Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772116/
https://www.ncbi.nlm.nih.gov/pubmed/24069564
http://dx.doi.org/10.4161/jkst.25353
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