JAK-STAT signaling in stem cells and their niches in Drosophila

JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems...

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Detalles Bibliográficos
Autor principal: Bausek, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Special Focus Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772118/
https://www.ncbi.nlm.nih.gov/pubmed/24069566
http://dx.doi.org/10.4161/jkst.25686
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author Bausek, Nina
author_facet Bausek, Nina
author_sort Bausek, Nina
collection PubMed
description JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems in Drosophila. Tightly controlled levels of JAK-STAT signaling are required for stem cell maintenance and self-renewal, as hyperactivation of the pathway is associated with stem cell overproliferation. JAK-STAT activity is further essential for anchoring the stem cells in their respective niches by regulating different adhesion molecules.
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spelling pubmed-37721182013-09-25 JAK-STAT signaling in stem cells and their niches in Drosophila Bausek, Nina JAKSTAT Special Focus Review JAK-STAT signaling is a highly conserved regulator of stem cells and their niches. Aberrant activation in hematopoietic stem cells is the underlying cause of a majority of myeloproliferative diseases. This review will focus on the roles of JAK-STAT activity in three different adult stem cell systems in Drosophila. Tightly controlled levels of JAK-STAT signaling are required for stem cell maintenance and self-renewal, as hyperactivation of the pathway is associated with stem cell overproliferation. JAK-STAT activity is further essential for anchoring the stem cells in their respective niches by regulating different adhesion molecules. Landes Bioscience 2013-07-01 2013-07-15 /pmc/articles/PMC3772118/ /pubmed/24069566 http://dx.doi.org/10.4161/jkst.25686 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Special Focus Review
Bausek, Nina
JAK-STAT signaling in stem cells and their niches in Drosophila
title JAK-STAT signaling in stem cells and their niches in Drosophila
title_full JAK-STAT signaling in stem cells and their niches in Drosophila
title_fullStr JAK-STAT signaling in stem cells and their niches in Drosophila
title_full_unstemmed JAK-STAT signaling in stem cells and their niches in Drosophila
title_short JAK-STAT signaling in stem cells and their niches in Drosophila
title_sort jak-stat signaling in stem cells and their niches in drosophila
topic Special Focus Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772118/
https://www.ncbi.nlm.nih.gov/pubmed/24069566
http://dx.doi.org/10.4161/jkst.25686
work_keys_str_mv AT bauseknina jakstatsignalinginstemcellsandtheirnichesindrosophila

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