Cargando…

Roles of Phosphate Recognition in Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase (IPK1) Substrate Binding and Activation

Inositol phosphate kinases (IPKs) sequentially phosphorylate inositol phosphates (IPs) to yield a group of small signaling molecules involved in diverse cellular processes. IPK1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) phosphorylates inositol 1,3,4,5,6-pentakisphosphate to inositol 1,2,3,4,5,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gosein, Varin, Miller, Gregory J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772240/ https://www.ncbi.nlm.nih.gov/pubmed/23884422 http://dx.doi.org/10.1074/jbc.M113.487777

Ejemplares similares

Development of Low Phytate Rice by RNAi Mediated Seed-Specific Silencing of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Gene (IPK1)
por: Ali, Nusrat, et al.
Publicado: (2013)

The behaviour of inositol 1,3,4,5,6-pentakisphosphate in the presence of the major biological metal cations
por: Veiga, Nicolás, et al.
Publicado: (2009)

An ATP-responsive metabolic cassette comprised of inositol tris/tetrakisphosphate kinase 1 (ITPK1) and inositol pentakisphosphate 2-kinase (IPK1) buffers diphosphosphoinositol phosphate levels
por: Whitfield, Hayley, et al.
Publicado: (2020)

A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate
por: Falasca, M, et al.
Publicado: (2010)

The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function
por: Franco-Echevarría, Elsa, et al.
Publicado: (2017)

RNAi-Mediated Downregulation of Inositol Pentakisphosphate Kinase (IPK1) in Wheat Grains Decreases Phytic Acid Levels and Increases Fe and Zn Accumulation
por: Aggarwal, Sipla, et al.
Publicado: (2018)

An Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase 1 Mutant with a 33-nt Deletion Showed Enhanced Tolerance to Salt and Drought Stress in Rice
por: Jiang, Meng, et al.
Publicado: (2020)

CRISPR/Cas9 mediated disruption of Inositol Pentakisphosphate 2-Kinase 1 (TaIPK1) reduces phytic acid and improves iron and zinc accumulation in wheat grains
por: Ibrahim, Saira, et al.
Publicado: (2021)

Diversification in the inositol tris/tetrakisphosphate kinase (ITPK) family: crystal structure and enzymology of the outlier AtITPK4
por: Whitfield, Hayley L., et al.
Publicado: (2023)

Inframolecular acid–base and coordination properties towards Na(+) and Mg(2+) of myo-inositol 1,3,4,5,6-pentakisphosphate: a structural approach to biologically relevant species
por: Veiga, Nicolás, et al.
Publicado: (2013)

Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates
por: Zauner, Florian B., et al.
Publicado: (2018)

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
por: Malcolm, Tess R., et al.
Publicado: (2021)

Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification
por: Mitra, Partha S., et al.
Publicado: (2011)

Active-site copper reduction promotes substrate binding of fungal lytic polysaccharide monooxygenase and reduces stability
por: Kracher, Daniel, et al.
Publicado: (2018)

Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
por: Yonesu, Kiyoaki, et al.
Publicado: (2011)

Inositol pyrophosphate synthesis by diphosphoinositol pentakisphosphate kinase-1 is regulated by phosphatidylinositol(4,5)bisphosphate
por: Nair, Vasudha S., et al.
Publicado: (2018)

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages
por: Kennedy, Edward M., et al.
Publicado: (2010)

Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing
por: Patel, Nikesh, et al.
Publicado: (2013)

Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity
por: Waz, Shaimaa, et al.
Publicado: (2017)

Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1
por: Paumann-Page, Martina, et al.
Publicado: (2017)

ATP and AMP Mutually Influence Their Interaction with the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) at Separate Binding Sites
por: Randak, Christoph O., et al.
Publicado: (2013)

Comparative Analysis of Histophilus somni Immunoglobulin-binding Protein A (IbpA) with Other Fic Domain-containing Enzymes Reveals Differences in Substrate and Nucleotide Specificities
por: Mattoo, Seema, et al.
Publicado: (2011)

Deconjugation of Nedd8 from Cul1 Is Directly Regulated by Skp1-F-box and Substrate, and the COP9 Signalosome Inhibits Deneddylated SCF by a Noncatalytic Mechanism
por: Emberley, Ethan D., et al.
Publicado: (2012)

The mechanism of a one-substrate transketolase reaction
por: Solovjeva, Olga N., et al.
Publicado: (2020)

Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactions
por: Jackson, Sean G, et al.
Publicado: (2011)

Proteomic discovery of substrates of the cardiovascular protease ADAMTS7
por: Colige, Alain, et al.
Publicado: (2019)

The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae
por: Asención Diez, Matías D., et al.
Publicado: (2017)

Identification of Key Residues Determining Species Differences in Inhibitor Binding of Microsomal Prostaglandin E Synthase-1
por: Pawelzik, Sven-Christian, et al.
Publicado: (2010)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Demonstration of Phosphoryl Group Transfer Indicates That the ATP-binding Cassette (ABC) Transporter Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Exhibits Adenylate Kinase Activity
por: Randak, Christoph O., et al.
Publicado: (2012)

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes
por: Menon, Binuraj R. K., et al.
Publicado: (2014)

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes
por: Soo, Valerie W. C., et al.
Publicado: (2016)

Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia
por: Dong, Qian, et al.
Publicado: (2015)

Resurrection of ancestral effector caspases identifies novel networks for evolution of substrate specificity
por: Grinshpon, Robert D., et al.
Publicado: (2019)

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA)
por: Ahangar, Mohd Syed, et al.
Publicado: (2018)

Substrate Oxidation by Indoleamine 2,3-Dioxygenase: EVIDENCE FOR A COMMON REACTION MECHANISM
por: Booth, Elizabeth S., et al.
Publicado: (2015)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6
por: Islam, Md. Saiful, et al.
Publicado: (2019)

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity
por: Elnatan, Daniel, et al.
Publicado: (2018)

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
por: Söderholm, Annika, et al.
Publicado: (2020)

Structural basis for substrate specificity of methylsuccinyl-CoA dehydrogenase, an unusual member of the acyl-CoA dehydrogenase family
por: Schwander, Thomas, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_m4rd4nn7cgjuauoheg7cp9i8lq