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The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research
Animal models have long been developed for cardiovascular research. These animal models have been helpful in understanding disease, discovering potential therapeutics, and predicting efficacy. Despite many efforts, however, translational study has been underestimated. Recently, investigations have i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Cardiology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772295/ https://www.ncbi.nlm.nih.gov/pubmed/24044009 http://dx.doi.org/10.4070/kcj.2013.43.8.511 |
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author | Kwon, Sung Uk Yeung, Alan C Ikeno, Fumiaki |
author_facet | Kwon, Sung Uk Yeung, Alan C Ikeno, Fumiaki |
author_sort | Kwon, Sung Uk |
collection | PubMed |
description | Animal models have long been developed for cardiovascular research. These animal models have been helpful in understanding disease, discovering potential therapeutics, and predicting efficacy. Despite many efforts, however, translational study has been underestimated. Recently, investigations have identified stem cell treatment as a potentially promising cell therapy for regenerative medicine, largely because of the stem cell's ability to differentiate into many functional cell types. Stem cells promise a new era of cell-based therapy for salvaging the heart. However, stem cells have the potential risk of tumor formation. These properties of stem cells are considered a major concern over the efficacy of cell therapy. The translational/preclinical study of stem cells is essential but only at the beginning stages. What types of heart disease are indicated for stem cell therapy, what type of stem cell, what type of animal model, how do we deliver stem cells, and how do we improve heart function? These may be the key issues that the settlement of which would facilitate the transition of stem cell research from bench to bedside. In this review article, we discuss state-of-the-art technology in stem cell therapies for cardiovascular diseases. |
format | Online Article Text |
id | pubmed-3772295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-37722952013-09-16 The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research Kwon, Sung Uk Yeung, Alan C Ikeno, Fumiaki Korean Circ J Review Animal models have long been developed for cardiovascular research. These animal models have been helpful in understanding disease, discovering potential therapeutics, and predicting efficacy. Despite many efforts, however, translational study has been underestimated. Recently, investigations have identified stem cell treatment as a potentially promising cell therapy for regenerative medicine, largely because of the stem cell's ability to differentiate into many functional cell types. Stem cells promise a new era of cell-based therapy for salvaging the heart. However, stem cells have the potential risk of tumor formation. These properties of stem cells are considered a major concern over the efficacy of cell therapy. The translational/preclinical study of stem cells is essential but only at the beginning stages. What types of heart disease are indicated for stem cell therapy, what type of stem cell, what type of animal model, how do we deliver stem cells, and how do we improve heart function? These may be the key issues that the settlement of which would facilitate the transition of stem cell research from bench to bedside. In this review article, we discuss state-of-the-art technology in stem cell therapies for cardiovascular diseases. The Korean Society of Cardiology 2013-08 2013-08-31 /pmc/articles/PMC3772295/ /pubmed/24044009 http://dx.doi.org/10.4070/kcj.2013.43.8.511 Text en Copyright © 2013 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kwon, Sung Uk Yeung, Alan C Ikeno, Fumiaki The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research |
title | The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research |
title_full | The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research |
title_fullStr | The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research |
title_full_unstemmed | The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research |
title_short | The Role of Large Animal Studies in Cardiac Regenerative Therapy Concise Review of Translational Stem Cell Research |
title_sort | role of large animal studies in cardiac regenerative therapy concise review of translational stem cell research |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772295/ https://www.ncbi.nlm.nih.gov/pubmed/24044009 http://dx.doi.org/10.4070/kcj.2013.43.8.511 |
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