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(1R*,21S*,22R*,24S*)-Methyl ethyl 2-[23-hy­droxy-22,24-diphenyl-8,11,14-trioxa-25-aza­tetra­cyclo­[19.3.1.0(2,7).0(15,20)]penta­cosa-2,4,6,15(20),16,18-hexaen-25-yl]but-2-enedioate

The title compound, C(40)H(41)NO(8), is a product of the reduction of the cyclic carbonyl group of the γ-piperidone subunit of the aza-14-crown-4 ether with subsequent re-esterification of its dimethyl butenoate substituent into a monoethyl monomethyl group. The aza­crown macrocycle exhibits a bowl...

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Detalles Bibliográficos
Autores principales: Hieu, Truong Hong, Anh, Le Tuan, Soldatenkov, Anatoly T., Gorchakova, Olga S., Khrustalev, Victor N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772461/
https://www.ncbi.nlm.nih.gov/pubmed/24046604
http://dx.doi.org/10.1107/S1600536813014748
Descripción
Sumario:The title compound, C(40)H(41)NO(8), is a product of the reduction of the cyclic carbonyl group of the γ-piperidone subunit of the aza-14-crown-4 ether with subsequent re-esterification of its dimethyl butenoate substituent into a monoethyl monomethyl group. The aza­crown macrocycle exhibits a bowl conformation with a dihedral angle of 70.82 (5)° between the benzene rings fused to it. The piperidine ring adopts a chair conformation and the methyl ethyl ethyl­enedi­carboxyl­ate fragment has a cis conformation, with a dihedral angle of 66.51 (7)° between the two carboxyl­ate groups. The ethyl group is disordered over two sites with occupancies of 0.70 (1):0.30 (1). In the crystal, mol­ecules form inversion dimers, via pairs of O—H⋯O hydrogen bonds, that stack along the a axis.