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Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate
In the title compound, C(29)H(23)ClN(4)O(4), the quinazoline-indole system and the indolin-2-one system are each essentially planar, with maximum deviations from their mean planes of 0.150 (2) and 0.072 (2) Å, respectively. The central pyrrolidine ring adopts a twisted conformation on the C—C bond i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772491/ https://www.ncbi.nlm.nih.gov/pubmed/24046634 http://dx.doi.org/10.1107/S1600536813015146 |
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author | Kannan, Piskala Subburaman Lanka, Srinu Thennarasu, Sathiah Govindan, E. SubbiahPandi, Arunachalathevar |
author_facet | Kannan, Piskala Subburaman Lanka, Srinu Thennarasu, Sathiah Govindan, E. SubbiahPandi, Arunachalathevar |
author_sort | Kannan, Piskala Subburaman |
collection | PubMed |
description | In the title compound, C(29)H(23)ClN(4)O(4), the quinazoline-indole system and the indolin-2-one system are each essentially planar, with maximum deviations from their mean planes of 0.150 (2) and 0.072 (2) Å, respectively. The central pyrrolidine ring adopts a twisted conformation on the C—C bond involving the spiro C atoms. Its mean plane forms dihedral angles of 83.37 (9) and 86.56 (8)°, respectively, with the indole rings of the indolin-2-one and quinazoline-indole systems. In the crystal, molecules are linked via pairs of N—H⋯O hydrogen bonds, forming inversion dimers. The dimers are linked via C—H⋯O hydrogen bonds, forming chains propagating along [001]. |
format | Online Article Text |
id | pubmed-3772491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-37724912013-09-17 Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate Kannan, Piskala Subburaman Lanka, Srinu Thennarasu, Sathiah Govindan, E. SubbiahPandi, Arunachalathevar Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(29)H(23)ClN(4)O(4), the quinazoline-indole system and the indolin-2-one system are each essentially planar, with maximum deviations from their mean planes of 0.150 (2) and 0.072 (2) Å, respectively. The central pyrrolidine ring adopts a twisted conformation on the C—C bond involving the spiro C atoms. Its mean plane forms dihedral angles of 83.37 (9) and 86.56 (8)°, respectively, with the indole rings of the indolin-2-one and quinazoline-indole systems. In the crystal, molecules are linked via pairs of N—H⋯O hydrogen bonds, forming inversion dimers. The dimers are linked via C—H⋯O hydrogen bonds, forming chains propagating along [001]. International Union of Crystallography 2013-06-08 /pmc/articles/PMC3772491/ /pubmed/24046634 http://dx.doi.org/10.1107/S1600536813015146 Text en © Kannan et al. 2013 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Kannan, Piskala Subburaman Lanka, Srinu Thennarasu, Sathiah Govindan, E. SubbiahPandi, Arunachalathevar Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
title | Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
title_full | Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
title_fullStr | Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
title_full_unstemmed | Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
title_short | Ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′H-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
title_sort | ethyl 8′′-chloro-1′-methyl-2,12′′-dioxo-12′′h-dispiro[indoline-3,2′-pyrrolidine- 3′,6′′-indolo[2,1-b]quinazoline]-4′-carboxylate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772491/ https://www.ncbi.nlm.nih.gov/pubmed/24046634 http://dx.doi.org/10.1107/S1600536813015146 |
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