Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EM...

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Detalles Bibliográficos
Autores principales: Espinoza, Ingrid, Pochampally, Radhika, Xing, Fei, Watabe, Kounosuke, Miele, Lucio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772757/
https://www.ncbi.nlm.nih.gov/pubmed/24043949
http://dx.doi.org/10.2147/OTT.S36162
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author Espinoza, Ingrid
Pochampally, Radhika
Xing, Fei
Watabe, Kounosuke
Miele, Lucio
author_facet Espinoza, Ingrid
Pochampally, Radhika
Xing, Fei
Watabe, Kounosuke
Miele, Lucio
author_sort Espinoza, Ingrid
collection PubMed
description Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the “stemness” program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.
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spelling pubmed-37727572013-09-16 Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition Espinoza, Ingrid Pochampally, Radhika Xing, Fei Watabe, Kounosuke Miele, Lucio Onco Targets Ther Review Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the “stemness” program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process. Dove Medical Press 2013-09-06 /pmc/articles/PMC3772757/ /pubmed/24043949 http://dx.doi.org/10.2147/OTT.S36162 Text en © 2013 Espinoza et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.
spellingShingle Review
Espinoza, Ingrid
Pochampally, Radhika
Xing, Fei
Watabe, Kounosuke
Miele, Lucio
Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
title Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
title_full Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
title_fullStr Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
title_full_unstemmed Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
title_short Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
title_sort notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772757/
https://www.ncbi.nlm.nih.gov/pubmed/24043949
http://dx.doi.org/10.2147/OTT.S36162
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AT watabekounosuke notchsignalingtargetingcancerstemcellsandepithelialtomesenchymaltransition
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