Cargando…

Fusion Protein Vaccines Targeting Two Tumor Antigens Generate Synergistic Anti-Tumor Effects

INTRODUCTION: Human papillomavirus (HPV) has been consistently implicated in causing several kinds of malignancies, and two HPV oncogenes, E6 and E7, represent two potential target antigens for cancer vaccines. We developed two fusion protein vaccines, PE(ΔIII)/E6 and PE(ΔIII)/E7 by targeting these...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Wen-Fang, Chang, Ming-Cheng, Sun, Wei-Zen, Jen, Yu-Wei, Liao, Chao-Wei, Chen, Yun-Yuan, Chen, Chi-An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772923/ https://www.ncbi.nlm.nih.gov/pubmed/24058440 http://dx.doi.org/10.1371/journal.pone.0071216

Ejemplares similares

mTOR Inhibitors Can Enhance the Anti-Tumor Effects of DNA Vaccines through Modulating Dendritic Cell Function in the Tumor Microenvironment
por: Chen, Yu-Li, et al.
Publicado: (2019)

Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma
por: Cheng, Yang, et al.
Publicado: (2017)

Depletion of Regulatory T Lymphocytes Reverses the Imbalance between Pro- and Anti-Tumor Immunities via Enhancing Antigen-Specific T Cell Immune Responses
por: Chen, Yu-Li, et al.
Publicado: (2012)

Synergistic anti-tumor therapy by a comb-like multifunctional antibody nanoarray with exceptionally potent activity
por: Li, Huafei, et al.
Publicado: (2015)

Improved generation of anti-tumor immunity by antigen dose limitation
por: Shofner, Joshua D, et al.
Publicado: (2007)

Amplified intracellular Ca(2+) for synergistic anti-tumor therapy of microwave ablation and chemotherapy
por: Dou, Jian-ping, et al.
Publicado: (2019)

Synergistic anti-tumor effects of liraglutide with metformin on pancreatic cancer cells
por: Lu, Ran, et al.
Publicado: (2018)

Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique?
por: Wagner, Samuel C., et al.
Publicado: (2015)

Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin
por: Ishiguro, Tatsuaki, et al.
Publicado: (2022)

Identification of tumor antigens and immune subtypes of hepatocellular carcinoma for mRNA vaccine development
por: Lu, Tai-Liang, et al.
Publicado: (2023)

Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas
por: Cheng, Yu-Chen, et al.
Publicado: (2016)

Identifying Potential Tumor Antigens and Antigens-Related Subtypes in Hepatocellular Carcinoma for mRNA Vaccine Development
por: Liao, Weiran, et al.
Publicado: (2022)

TWO KINDS OF ANTIGEN SUPPRESSION IN TUMOR CELLS REVEALED BY CELL FUSION
por: Klein, George, et al.
Publicado: (1972)

Generation of αGal-enhanced bifunctional tumor vaccine
por: He, Jian, et al.
Publicado: (2022)

Ruxolitinib synergistically enhances the anti-tumor activity of paclitaxel in human ovarian cancer
por: Han, Ernest S., et al.
Publicado: (2018)

Synergistic Anti-Tumor Activity by Targeting Multiple Signaling Pathways in Ovarian Cancer
por: Wen, Wei, et al.
Publicado: (2020)

Tumor-Targeted Immunotherapy by Using Primary Adipose-Derived Stem Cells and an Antigen-Specific Protein Vaccine
por: Lu, Jui-Hua, et al.
Publicado: (2018)

Highly Correlated Recurrence Prognosis in Patients with Metastatic Colorectal Cancer by Synergistic Consideration of Circulating Tumor Cells/Microemboli and Tumor Markers CEA/CA19-9
por: Chu, Hsueh-Yao, et al.
Publicado: (2021)

The Landscape of Tumor Fusion Neoantigens: A Pan-Cancer Analysis
por: Wei, Zhiting, et al.
Publicado: (2019)

Oxygen and Pt(II) self-generating conjugate for synergistic photo-chemo therapy of hypoxic tumor
por: Xu, Shuting, et al.
Publicado: (2018)

Effect of Multiple Vaccinations with Tumor Cell-Based Vaccine with Codon-Modified GM-CSF on Tumor Growth in a Mouse Model
por: Qiu, Jiantai Timothy, et al.
Publicado: (2019)

Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses
por: Hsieh, Ming-Shu, et al.
Publicado: (2021)

Dual-Ligand Synergistic Targeting Anti-Tumor Nanoplatforms with Cascade-Responsive Drug Release
por: Luo, Fang, et al.
Publicado: (2023)

Tumor-Targeting Ability of Novel Anti-Prostate-Specific Membrane Antigen Antibodies
por: Hsieh, Hsin-Hua, et al.
Publicado: (2022)

A dendritic/tumor fusion cell vaccine enhances efficacy of nanobody-based CAR-T cells against solid tumor
por: Sun, Shuyang, et al.
Publicado: (2023)

Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy
por: Lin, Wen-Wei, et al.
Publicado: (2021)

Enhancement of anti-murine colon cancer immunity by fusion of a SARS fragment to a low-immunogenic carcinoembryonic antigen
por: Lin, Chen-Si, et al.
Publicado: (2012)

Green Fluorescent Protein and Phase-Contrast Image Fusion via Generative Adversarial Networks
por: Tang, Wei, et al.
Publicado: (2019)

Cinnamaldehyde-modified chitosan hybrid nanoparticles for DOX delivering to produce synergistic anti-tumor effects
por: Zhou, Zuoqin, et al.
Publicado: (2022)

B lymphocytes as direct antigen-presenting cells for anti-tumor DNA vaccines
por: Colluru, Viswa Teja, et al.
Publicado: (2016)

Whole-cell tumor vaccines desialylated to uncover tumor antigenic Gal/GalNAc epitopes elicit anti-tumor immunity
por: Huang, Jianmei, et al.
Publicado: (2022)

Generation of fusion protein EGFRvIII-HBcAg and its anti-tumor effect in vivo
por: Duan, Xiao-yi, et al.
Publicado: (2009)

Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment
por: Yan, Wan-Lun, et al.
Publicado: (2021)

HDAC6 inhibitor WT161 performs anti-tumor effect on osteosarcoma and synergistically interacts with 5-FU
por: Sun, Jun, et al.
Publicado: (2021)

Synergistic Anti-Tumor Effect of Simvastatin Combined to Chemotherapy in Osteosarcoma
por: Mangelinck, Adèle, et al.
Publicado: (2021)

Dual inhibition of BTLA and PD-1 can enhance therapeutic efficacy of paclitaxel on intraperitoneally disseminated tumors
por: Sun, Wei-Zen, et al.
Publicado: (2023)

Human melanoma immunotherapy using tumor antigen-specific T cells generated in humanized mice
por: Hu, Zheng, et al.
Publicado: (2016)

An Endogenous Vaccine Based on Fluorophores and Multivalent Immunoadjuvants Regulates Tumor Micro-Environment for Synergistic Photothermal and Immunotherapy
por: Li, Ling, et al.
Publicado: (2018)

Anti-tumor effects of a recombinant anti-prostate specific membrane antigen immunotoxin against prostate cancer cells
por: Meng, Ping, et al.
Publicado: (2017)

Decellularized Lymph Node Scaffolding as a Carrier for Dendritic Cells to Induce Anti-Tumor Immunity
por: Lin, Hung-Jun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d8hjej7f8u9nk04cl3feh693cf