Cargando…
The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization
BACKGROUND: Increasing evidence supports the immunomodulatory effect of vitamin D on allergic diseases. The combined role of prenatal and postnatal vitamin D status in the development of food sensitization (FS) and food allergy remains under-studied. METHODS: 460 children in the Boston Birth Cohort...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773018/ https://www.ncbi.nlm.nih.gov/pubmed/23797532 http://dx.doi.org/10.1038/pr.2013.110 |
_version_ | 1782284395601723392 |
---|---|
author | Liu, Xin Arguelles, Lester Zhou, Ying Wang, Guoying Chen, Qi Tsai, Hui-Ju Hong, Xiumei Liu, Rong Price, Heather E Pearson, Colleen Apollon, Stephanie Cruz, Natalie Schleimer, Robert Langman, Craig B. Pongracic, Jacqueline Wang, Xiaobin |
author_facet | Liu, Xin Arguelles, Lester Zhou, Ying Wang, Guoying Chen, Qi Tsai, Hui-Ju Hong, Xiumei Liu, Rong Price, Heather E Pearson, Colleen Apollon, Stephanie Cruz, Natalie Schleimer, Robert Langman, Craig B. Pongracic, Jacqueline Wang, Xiaobin |
author_sort | Liu, Xin |
collection | PubMed |
description | BACKGROUND: Increasing evidence supports the immunomodulatory effect of vitamin D on allergic diseases. The combined role of prenatal and postnatal vitamin D status in the development of food sensitization (FS) and food allergy remains under-studied. METHODS: 460 children in the Boston Birth Cohort had plasma 25(OH)D measured at birth and early childhood, and were genotyped for rs2243250 (C-590T) in the IL4 gene. We defined FS as specific IgE ≥0.35kUA/L to any of eight common food allergens; and persistently low vitamin D status as cord blood 25(OH)D <11ng/ml and postnatal 25(OH)D <30ng/ml. RESULTS: We observed a moderate correlation between cord blood 25(OH)D at birth and venous blood 25(OH)D measured at 2–3 years (r=0.63), but a weak correlation at <1 year (r=0.28). There was no association between low vitamin D status and FS at any single time point alone. However, in combination, persistence of low vitamin D status at birth and early childhood increased the risk of FS (OR=2.03, 95%CI:1.02–4.04), particularly among children carrying the C allele of rs2243250 (OR=3.23, 95%CI:1.37–7.60). CONCLUSIONS: Prenatal and early postnatal vitamin D levels, along with individual genetic susceptibility, should be considered in assessing the role of vitamin D in the development of FS and food allergy. |
format | Online Article Text |
id | pubmed-3773018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
record_format | MEDLINE/PubMed |
spelling | pubmed-37730182014-03-01 The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization Liu, Xin Arguelles, Lester Zhou, Ying Wang, Guoying Chen, Qi Tsai, Hui-Ju Hong, Xiumei Liu, Rong Price, Heather E Pearson, Colleen Apollon, Stephanie Cruz, Natalie Schleimer, Robert Langman, Craig B. Pongracic, Jacqueline Wang, Xiaobin Pediatr Res Article BACKGROUND: Increasing evidence supports the immunomodulatory effect of vitamin D on allergic diseases. The combined role of prenatal and postnatal vitamin D status in the development of food sensitization (FS) and food allergy remains under-studied. METHODS: 460 children in the Boston Birth Cohort had plasma 25(OH)D measured at birth and early childhood, and were genotyped for rs2243250 (C-590T) in the IL4 gene. We defined FS as specific IgE ≥0.35kUA/L to any of eight common food allergens; and persistently low vitamin D status as cord blood 25(OH)D <11ng/ml and postnatal 25(OH)D <30ng/ml. RESULTS: We observed a moderate correlation between cord blood 25(OH)D at birth and venous blood 25(OH)D measured at 2–3 years (r=0.63), but a weak correlation at <1 year (r=0.28). There was no association between low vitamin D status and FS at any single time point alone. However, in combination, persistence of low vitamin D status at birth and early childhood increased the risk of FS (OR=2.03, 95%CI:1.02–4.04), particularly among children carrying the C allele of rs2243250 (OR=3.23, 95%CI:1.37–7.60). CONCLUSIONS: Prenatal and early postnatal vitamin D levels, along with individual genetic susceptibility, should be considered in assessing the role of vitamin D in the development of FS and food allergy. 2013-06-24 2013-09 /pmc/articles/PMC3773018/ /pubmed/23797532 http://dx.doi.org/10.1038/pr.2013.110 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Liu, Xin Arguelles, Lester Zhou, Ying Wang, Guoying Chen, Qi Tsai, Hui-Ju Hong, Xiumei Liu, Rong Price, Heather E Pearson, Colleen Apollon, Stephanie Cruz, Natalie Schleimer, Robert Langman, Craig B. Pongracic, Jacqueline Wang, Xiaobin The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization |
title | The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization |
title_full | The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization |
title_fullStr | The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization |
title_full_unstemmed | The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization |
title_short | The Longitudinal Trajectory of Vitamin D Status from Birth to Early Childhood on the Development of Food Sensitization |
title_sort | longitudinal trajectory of vitamin d status from birth to early childhood on the development of food sensitization |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773018/ https://www.ncbi.nlm.nih.gov/pubmed/23797532 http://dx.doi.org/10.1038/pr.2013.110 |
work_keys_str_mv | AT liuxin thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT arguelleslester thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT zhouying thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT wangguoying thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT chenqi thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT tsaihuiju thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT hongxiumei thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT liurong thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT priceheathere thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT pearsoncolleen thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT apollonstephanie thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT cruznatalie thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT schleimerrobert thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT langmancraigb thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT pongracicjacqueline thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT wangxiaobin thelongitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT liuxin longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT arguelleslester longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT zhouying longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT wangguoying longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT chenqi longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT tsaihuiju longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT hongxiumei longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT liurong longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT priceheathere longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT pearsoncolleen longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT apollonstephanie longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT cruznatalie longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT schleimerrobert longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT langmancraigb longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT pongracicjacqueline longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization AT wangxiaobin longitudinaltrajectoryofvitamindstatusfrombirthtoearlychildhoodonthedevelopmentoffoodsensitization |