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Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

The objective of this study was to examine the effectiveness of resveratrol in lowering blood glucose in the presence of standard antidiabetic treatment in patients with type 2 diabetes, in a randomized placebo-controlled double-blinded parallel clinical trial. A total of 66 subjects with type 2 dia...

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Autores principales: Movahed, Ali, Nabipour, Iraj, Lieben Louis, Xavier, Thandapilly, Sijo Joseph, Yu, Liping, Kalantarhormozi, Mohammadreza, Rekabpour, Seyed Javad, Netticadan, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773903/
https://www.ncbi.nlm.nih.gov/pubmed/24073011
http://dx.doi.org/10.1155/2013/851267
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author Movahed, Ali
Nabipour, Iraj
Lieben Louis, Xavier
Thandapilly, Sijo Joseph
Yu, Liping
Kalantarhormozi, Mohammadreza
Rekabpour, Seyed Javad
Netticadan, Thomas
author_facet Movahed, Ali
Nabipour, Iraj
Lieben Louis, Xavier
Thandapilly, Sijo Joseph
Yu, Liping
Kalantarhormozi, Mohammadreza
Rekabpour, Seyed Javad
Netticadan, Thomas
author_sort Movahed, Ali
collection PubMed
description The objective of this study was to examine the effectiveness of resveratrol in lowering blood glucose in the presence of standard antidiabetic treatment in patients with type 2 diabetes, in a randomized placebo-controlled double-blinded parallel clinical trial. A total of 66 subjects with type 2 diabetes were enrolled in this study and randomly assigned to intervention group which was supplemented with resveratrol at a dose 1 g/day for 45 days and control group which received placebo tablets. Body weight, blood pressure, fasting blood glucose, haemoglobin A1c, insulin, homeostatic assessments for insulin resistance, triglycerides, total cholesterol, low density lipoprotein, high density lipoprotein, and markers of liver and kidney damage were measured at baseline and after 45 days of resveratrol or placebo supplementation. Resveratrol treatment significantly decreased systolic blood pressure, fasting blood glucose, haemoglobin A1c, insulin, and insulin resistance, while HDL was significantly increased, when compared to their baseline levels. On the other hand, the placebo group had slightly increased fasting glucose and LDL when compared to their baseline levels. Liver and kidney function markers were unchanged in the intervention group. Overall, this study showed that resveratrol supplementation exerted strong antidiabetic effects in patients with type 2 diabetes.
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spelling pubmed-37739032013-09-26 Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients Movahed, Ali Nabipour, Iraj Lieben Louis, Xavier Thandapilly, Sijo Joseph Yu, Liping Kalantarhormozi, Mohammadreza Rekabpour, Seyed Javad Netticadan, Thomas Evid Based Complement Alternat Med Research Article The objective of this study was to examine the effectiveness of resveratrol in lowering blood glucose in the presence of standard antidiabetic treatment in patients with type 2 diabetes, in a randomized placebo-controlled double-blinded parallel clinical trial. A total of 66 subjects with type 2 diabetes were enrolled in this study and randomly assigned to intervention group which was supplemented with resveratrol at a dose 1 g/day for 45 days and control group which received placebo tablets. Body weight, blood pressure, fasting blood glucose, haemoglobin A1c, insulin, homeostatic assessments for insulin resistance, triglycerides, total cholesterol, low density lipoprotein, high density lipoprotein, and markers of liver and kidney damage were measured at baseline and after 45 days of resveratrol or placebo supplementation. Resveratrol treatment significantly decreased systolic blood pressure, fasting blood glucose, haemoglobin A1c, insulin, and insulin resistance, while HDL was significantly increased, when compared to their baseline levels. On the other hand, the placebo group had slightly increased fasting glucose and LDL when compared to their baseline levels. Liver and kidney function markers were unchanged in the intervention group. Overall, this study showed that resveratrol supplementation exerted strong antidiabetic effects in patients with type 2 diabetes. Hindawi Publishing Corporation 2013 2013-09-01 /pmc/articles/PMC3773903/ /pubmed/24073011 http://dx.doi.org/10.1155/2013/851267 Text en Copyright © 2013 Ali Movahed et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Movahed, Ali
Nabipour, Iraj
Lieben Louis, Xavier
Thandapilly, Sijo Joseph
Yu, Liping
Kalantarhormozi, Mohammadreza
Rekabpour, Seyed Javad
Netticadan, Thomas
Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
title Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
title_full Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
title_fullStr Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
title_full_unstemmed Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
title_short Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients
title_sort antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773903/
https://www.ncbi.nlm.nih.gov/pubmed/24073011
http://dx.doi.org/10.1155/2013/851267
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