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Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications

The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1 : 2 and 1 : 5 in Tetrahydrofuran (THF)...

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Detalles Bibliográficos
Autores principales: Istanbullu, Hilal, Ahmed, Sofia, Sheraz, Muhammad Ali, Rehman, Ihtesham ur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773997/
https://www.ncbi.nlm.nih.gov/pubmed/24073394
http://dx.doi.org/10.1155/2013/178973
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author Istanbullu, Hilal
Ahmed, Sofia
Sheraz, Muhammad Ali
Rehman, Ihtesham ur
author_facet Istanbullu, Hilal
Ahmed, Sofia
Sheraz, Muhammad Ali
Rehman, Ihtesham ur
author_sort Istanbullu, Hilal
collection PubMed
description The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1 : 2 and 1 : 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1 : 2 to 1 : 5 ratios, respectively.
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spelling pubmed-37739972013-09-26 Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications Istanbullu, Hilal Ahmed, Sofia Sheraz, Muhammad Ali Rehman, Ihtesham ur Biomed Res Int Research Article The present study deals with the preparation of polyurethane (PU) films impregnated with a nonsteroidal anti-inflammatory drug, tolfenamic acid (TA). Solvent evaporation technique has been employed for the preparation of TA-PU films in two different ratios of 1 : 2 and 1 : 5 in Tetrahydrofuran (THF) or THF-ethanol mixtures. The prepared films were characterized using X-Ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and release studies. The results indicate transformation of crystalline TA to its amorphous form. The degree of crystallinity changes both by increasing the polymer concentration and solvent used for the film preparations. The release profiles of TA were also found to be affected, showing a decrease from approximately 50% to 25% from 1 : 2 to 1 : 5 ratios, respectively. Hindawi Publishing Corporation 2013 2013-09-01 /pmc/articles/PMC3773997/ /pubmed/24073394 http://dx.doi.org/10.1155/2013/178973 Text en Copyright © 2013 Hilal Istanbullu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Istanbullu, Hilal
Ahmed, Sofia
Sheraz, Muhammad Ali
Rehman, Ihtesham ur
Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
title Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
title_full Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
title_fullStr Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
title_full_unstemmed Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
title_short Development and Characterization of Novel Polyurethane Films Impregnated with Tolfenamic Acid for Therapeutic Applications
title_sort development and characterization of novel polyurethane films impregnated with tolfenamic acid for therapeutic applications
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773997/
https://www.ncbi.nlm.nih.gov/pubmed/24073394
http://dx.doi.org/10.1155/2013/178973
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