Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition

This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance of Candida albicans biofilms to amphotericin B (AmB). Coincubation of C. albicans biofilms with AmB and the Sod inhibitors N,N′-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced...

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Detalles Bibliográficos
Autores principales: De Brucker, Katrijn, Bink, Anna, Meert, Els, Cammue, Bruno P. A., Thevissen, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774027/
https://www.ncbi.nlm.nih.gov/pubmed/24078861
http://dx.doi.org/10.1155/2013/704654
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author De Brucker, Katrijn
Bink, Anna
Meert, Els
Cammue, Bruno P. A.
Thevissen, Karin
author_facet De Brucker, Katrijn
Bink, Anna
Meert, Els
Cammue, Bruno P. A.
Thevissen, Karin
author_sort De Brucker, Katrijn
collection PubMed
description This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance of Candida albicans biofilms to amphotericin B (AmB). Coincubation of C. albicans biofilms with AmB and the Sod inhibitors N,N′-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced viable biofilm cells and increased intracellular reactive oxygen species levels as compared to incubation of biofilm cells with AmB, DDC, or ATM alone. Hence, Sod inhibitors can be used to potentiate the activity of AmB against C. albicans biofilms.
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spelling pubmed-37740272013-09-29 Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition De Brucker, Katrijn Bink, Anna Meert, Els Cammue, Bruno P. A. Thevissen, Karin Oxid Med Cell Longev Research Article This study demonstrates a role for superoxide dismutases (Sods) in governing tolerance of Candida albicans biofilms to amphotericin B (AmB). Coincubation of C. albicans biofilms with AmB and the Sod inhibitors N,N′-diethyldithiocarbamate (DDC) or ammonium tetrathiomolybdate (ATM) resulted in reduced viable biofilm cells and increased intracellular reactive oxygen species levels as compared to incubation of biofilm cells with AmB, DDC, or ATM alone. Hence, Sod inhibitors can be used to potentiate the activity of AmB against C. albicans biofilms. Hindawi Publishing Corporation 2013 2013-09-01 /pmc/articles/PMC3774027/ /pubmed/24078861 http://dx.doi.org/10.1155/2013/704654 Text en Copyright © 2013 Katrijn De Brucker et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
De Brucker, Katrijn
Bink, Anna
Meert, Els
Cammue, Bruno P. A.
Thevissen, Karin
Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
title Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
title_full Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
title_fullStr Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
title_full_unstemmed Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
title_short Potentiation of Antibiofilm Activity of Amphotericin B by Superoxide Dismutase Inhibition
title_sort potentiation of antibiofilm activity of amphotericin b by superoxide dismutase inhibition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774027/
https://www.ncbi.nlm.nih.gov/pubmed/24078861
http://dx.doi.org/10.1155/2013/704654
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