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Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING

Many extracellular signals act via the Raf/MEK/ERK cascade in which kinetics, cell-cell variability, and sensitivity of the ERK response can all influence cell fate. Here we used automated microscopy to explore the effects of ERK-mediated negative feedback on these attributes in cells expressing end...

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Detalles Bibliográficos
Autores principales:	Perrett, Rebecca M, Fowkes, Robert C., Caunt, Christopher J., Tsaneva-Atanasova, Krasimira, Bowsher, Clive G., McArdle, Craig A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2013
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774369/ https://www.ncbi.nlm.nih.gov/pubmed/23754287 http://dx.doi.org/10.1074/jbc.M113.455345

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