A Mixed Mirror-image DNA/RNA Aptamer Inhibits Glucagon and Acutely Improves Glucose Tolerance in Models of Type 1 and Type 2 Diabetes

Excessive secretion of glucagon, a functional insulin antagonist, significantly contributes to hyperglycemia in type 1 and type 2 diabetes. Accordingly, immunoneutralization of glucagon or genetic deletion of the glucagon receptor improved glucose homeostasis in animal models of diabetes. Despite th...

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Detalles Bibliográficos
Autores principales: Vater, Axel, Sell, Simone, Kaczmarek, Przemyslaw, Maasch, Christian, Buchner, Klaus, Pruszynska-Oszmalek, Ewa, Kolodziejski, Pawel, Purschke, Werner G., Nowak, Krzysztof W., Strowski, Mathias Z., Klussmann, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774380/
https://www.ncbi.nlm.nih.gov/pubmed/23744070
http://dx.doi.org/10.1074/jbc.M112.444414

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