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Physical Motif Clustering within Intrinsically Disordered Nucleoporin Sequences Reveals Universal Functional Features

Bioinformatics of disordered proteins is especially challenging given high mutation rates for homologous proteins and that functionality may not be strongly related to sequence. Here we have performed a novel bioinformatic analysis, based on the spatial clustering of physically relevant features suc...

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Detalles Bibliográficos
Autores principales: Ando, David, Colvin, Michael, Rexach, Michael, Gopinathan, Ajay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774778/
https://www.ncbi.nlm.nih.gov/pubmed/24066078
http://dx.doi.org/10.1371/journal.pone.0073831