Heterozygous and Homozygous JAK2(V617F) States Modeled by Induced Pluripotent Stem Cells from Myeloproliferative Neoplasm Patients

JAK2(V617F) is the predominant mutation in myeloproliferative neoplasms (MPN). Modeling MPN in a human context might be helpful for the screening of molecules targeting JAK2 and its intracellular signaling. We describe here the derivation of induced pluripotent stem (iPS) cell lines from 2 polycythe...

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Detalles Bibliográficos
Autores principales: Saliba, Joseph, Hamidi, Sofiane, Lenglet, Gaëlle, Langlois, Thierry, Yin, Jingkui, Cabagnols, Xénia, Secardin, Lise, Legrand, Céline, Galy, Anne, Opolon, Paule, Benyahia, Baya, Solary, Eric, Bernard, Olivier A., Chen, Longyun, Debili, Najet, Raslova, Hana, Norol, Françoise, Vainchenker, William, Plo, Isabelle, Di Stefano, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774801/
https://www.ncbi.nlm.nih.gov/pubmed/24066127
http://dx.doi.org/10.1371/journal.pone.0074257

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