In Silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP(4) Mediated Feedbacks Increase Robustness

The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP(4)) is essential for thymocyte positive selection by regulating plasma-membrane association of the protein tyrosine kinase Itk downstream of the T cell receptor (TCR). IP(4) can act as a soluble analog of the phosphoinositide 3-...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sayak, Rigaud, Stephanie, Seok, Sang-Cheol, Fu, Guo, Prochenka, Agnieszka, Dworkin, Michael, Gascoigne, Nicholas R. J., Vieland, Veronica J., Sauer, Karsten, Das, Jayajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774804/
https://www.ncbi.nlm.nih.gov/pubmed/24066087
http://dx.doi.org/10.1371/journal.pone.0073937

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