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Roflumilast Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α and Chemokine Production by Human Lung Parenchyma

BACKGROUND: Roflumilast is the first phosphodiesterase-4 (PDE4) inhibitor to have been approved for the treatment of COPD. The anti-inflammatory profile of PDE4 inhibitors has not yet been explored in human lung tissues. We investigated the effects of roflumilast and its active metabolite roflumilas...

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Detalles Bibliográficos
Autores principales:	Buenestado, Amparo, Chaumais, Marie-Camille, Grassin-Delyle, Stanislas, Risse, Paul-André, Naline, Emmanuel, Longchampt, Elisabeth, Tenor, Hermann, Devillier, Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774805/ https://www.ncbi.nlm.nih.gov/pubmed/24066150 http://dx.doi.org/10.1371/journal.pone.0074640

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