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Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

Degradation of certain proteins through the ubiquitin-proteasome pathway is a common strategy taken by the key modulators responsible for stress responses. Kelch-like ECH-associated protein-1(Keap1), a substrate adaptor component of the Cullin3 (Cul3)-based ubiquitin E3 ligase complex, mediates the...

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Detalles Bibliográficos
Autores principales:	Jiang, Zheng-Yu, Chu, Hong-Xi, Xi, Mei-Yang, Yang, Ting-Ting, Jia, Jian-Min, Huang, Jing-Jie, Guo, Xiao-Ke, Zhang, Xiao-Jin, You, Qi-Dong, Sun, Hao-Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774807/ https://www.ncbi.nlm.nih.gov/pubmed/24066166 http://dx.doi.org/10.1371/journal.pone.0075076

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