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Biomarkers in Schizophrenia: A Brief Conceptual Consideration

Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 qu...

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Autores principales: Weickert, Cynthia S., Weickert, Thomas W., Pillai, Anil, Buckley, Peter F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774970/
https://www.ncbi.nlm.nih.gov/pubmed/24167344
http://dx.doi.org/10.1155/2013/510402
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author Weickert, Cynthia S.
Weickert, Thomas W.
Pillai, Anil
Buckley, Peter F.
author_facet Weickert, Cynthia S.
Weickert, Thomas W.
Pillai, Anil
Buckley, Peter F.
author_sort Weickert, Cynthia S.
collection PubMed
description Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery of biomarkers in schizophrenia? What is the best use of biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia.
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spelling pubmed-37749702013-10-01 Biomarkers in Schizophrenia: A Brief Conceptual Consideration Weickert, Cynthia S. Weickert, Thomas W. Pillai, Anil Buckley, Peter F. Dis Markers Review Article Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery of biomarkers in schizophrenia? What is the best use of biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia. Hindawi Publishing Corporation 2013 2013-07-21 /pmc/articles/PMC3774970/ /pubmed/24167344 http://dx.doi.org/10.1155/2013/510402 Text en Copyright © 2013 Cynthia S. Weickert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Weickert, Cynthia S.
Weickert, Thomas W.
Pillai, Anil
Buckley, Peter F.
Biomarkers in Schizophrenia: A Brief Conceptual Consideration
title Biomarkers in Schizophrenia: A Brief Conceptual Consideration
title_full Biomarkers in Schizophrenia: A Brief Conceptual Consideration
title_fullStr Biomarkers in Schizophrenia: A Brief Conceptual Consideration
title_full_unstemmed Biomarkers in Schizophrenia: A Brief Conceptual Consideration
title_short Biomarkers in Schizophrenia: A Brief Conceptual Consideration
title_sort biomarkers in schizophrenia: a brief conceptual consideration
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774970/
https://www.ncbi.nlm.nih.gov/pubmed/24167344
http://dx.doi.org/10.1155/2013/510402
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