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Biomarkers in Schizophrenia: A Brief Conceptual Consideration
Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 qu...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774970/ https://www.ncbi.nlm.nih.gov/pubmed/24167344 http://dx.doi.org/10.1155/2013/510402 |
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author | Weickert, Cynthia S. Weickert, Thomas W. Pillai, Anil Buckley, Peter F. |
author_facet | Weickert, Cynthia S. Weickert, Thomas W. Pillai, Anil Buckley, Peter F. |
author_sort | Weickert, Cynthia S. |
collection | PubMed |
description | Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery of biomarkers in schizophrenia? What is the best use of biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia. |
format | Online Article Text |
id | pubmed-3774970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-37749702013-10-01 Biomarkers in Schizophrenia: A Brief Conceptual Consideration Weickert, Cynthia S. Weickert, Thomas W. Pillai, Anil Buckley, Peter F. Dis Markers Review Article Biomarkers have been sought after in the field of schizophrenia research for decades. In this paper, we discuss some of the concepts around developing biomarkers in an effort to understand why the use of biomarkers for schizophrenia has not been realized. In particular, we address the following 4 questions. Why would we need a diagnostic biomarker for schizophrenia? How is a biomarker typically defined and how does that influence the discovery of biomarkers in schizophrenia? What is the best use of biomarkers in schizophrenia? Do any biomarkers for schizophrenia currently exist? Thus, while we suggest that no biomarker currently exists for schizophrenia, the heterogeneity associated with schizophrenia will most likely need to be taken into account which will result in multiple biomarkers that identify the multiple underlying pathophysiological processes involved in schizophrenia. Therefore, much additional work will be required prior to obtaining any well-established biomarkers for schizophrenia. Hindawi Publishing Corporation 2013 2013-07-21 /pmc/articles/PMC3774970/ /pubmed/24167344 http://dx.doi.org/10.1155/2013/510402 Text en Copyright © 2013 Cynthia S. Weickert et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Weickert, Cynthia S. Weickert, Thomas W. Pillai, Anil Buckley, Peter F. Biomarkers in Schizophrenia: A Brief Conceptual Consideration |
title | Biomarkers in Schizophrenia: A Brief Conceptual Consideration |
title_full | Biomarkers in Schizophrenia: A Brief Conceptual Consideration |
title_fullStr | Biomarkers in Schizophrenia: A Brief Conceptual Consideration |
title_full_unstemmed | Biomarkers in Schizophrenia: A Brief Conceptual Consideration |
title_short | Biomarkers in Schizophrenia: A Brief Conceptual Consideration |
title_sort | biomarkers in schizophrenia: a brief conceptual consideration |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774970/ https://www.ncbi.nlm.nih.gov/pubmed/24167344 http://dx.doi.org/10.1155/2013/510402 |
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